In Vivo Spectroscopy

1. Front Matter

   Pages i-xiii

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2. Localization in Clinical NMR Spectroscopy

   • Lizann Bolinger, Robert E. Lenkinski

   Pages 1-53

3. Off-Resonance Rotating Frame Spin—Lattice Relaxation

   • Thomas Schleich, G. Herbert Caines, Jan M. Rydzewski

   Pages 55-134

4. NMR Methods in Studies of Brain Ischemia

   • Lee-Hong Chang, Thomas L. James

   Pages 135-158

5. Shift-Reagent-Aided 23Na NMR Spectroscopy in Cellular, Tissue, and Whole-Organ Systems

   • Sandra K. Miller, Gabriel A. Elgavish

   Pages 159-240

6. In Vivo ¹⁹F NMR

   • Barry S. Selinsky, C. Tyler Burt

   Pages 241-276

7. In Vivo ²H NMR Studies of Cellular Metabolism

   • Robert E. London

   Pages 277-306

8. Some Applications of ESR to in Vivo Animal Studies and EPR Imaging

   • Lawrence J. Berliner, Hirotada Fujii

   Pages 307-319

9. Back Matter

   Pages 321-334

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In vivo nuclear magnetic and electron spin resonance spectroscopy is concerned, inter alia, with the noninvasive observation of metabolic changes in living systems, including animals and humans. Typically, the physiologi­ cal (or pathological) state of an organ or tissue is monitored. This multi­ faceted approach was developed during the 1980s. It is still a research technique, but will undoubtedly become a clinical tool. We are proud to present this volume (the eleventh of our series) in which some of the pioneers in this area summarize their contributions and review related literature. Bolinger and Lenkinski describe a variety of localization methods suitable for clinical applications of NMR spectroscopy. Schleich, Caines, and Rydzewski summarize their contributions to approaches involving off-resonance rotating frame relaxation and critically compare these with other NMR techniques that may yield similar information. Chang and James outline their approach and share their experience with the technical aspects 1 31 of H and P NMR spectroscopy and spatially localized spectroscopy in studies of brain ischemia. Sodium plays an important role in living systems, a key aspect being the large gradient between intra- and extracellular concentrations of sodium that is maintained by a variety of transport mechanisms. Miller and Elgavish give us a comprehensive review of an important research tool in this 23 area- Na NMR spectroscopy as aided by shift reagents.

• cells
• magnetic resonance
• metabolism
• spectroscopy
• tissue

• Department of Chemistry, The Ohio State University, Columbus, USA

  Lawrence J. Berliner

• Research Center, Hercules Incorporated, Wilmington, USA

  Jacques Reuben

Dr. Lawrence J. Berliner is currently Professor and Chair of the Department of Chemistry and Biochemistry at the University of Denver after retiring from Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR). He is the Series Editor for Biological Magnetic Resonance, which he launched in 1979.

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