Skip to main content
SpringerLink
Log in
Book cover

Developmental Origins of Health and Disease (DOHaD)

From Biological Basis to Clinical Significance

  • Book
  • © 2018

Overview

Editors:
  1. Takeo Kubota

    1. Faculty of Child Studies, Seitoku University, Matsudo, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Hideoki Fukuoka

    1. Research Organization for Nano & Life Innovation, Waseda University, Tokyo, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Covers numerous diseases associated with DOHaD
  • Presents an update of our understanding of molecular mechanisms for DOHaD
  • Based on the latest biological data
  • Suggests importance of early interventions for adult diseases

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1012)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (9 chapters)

  1. Front Matter

    Pages i-vii
    Download chapter PDF

  2. Biological Basis

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. One-Carbon Metabolism and Lipid Metabolism in DOHaD

      • Hideoki Fukuoka, Takeo Kubota
      Pages 3-9

    3. Novel Models of Epigenetic Gene Regulation in the Nutritional Environment

      • Kazuki Mochizuki, Natsuyo Hariya, Takeo Kubota
      Pages 11-18

    4. Epigenetic Switching and Neonatal Nutritional Environment

      • Koshi Hashimoto, Yoshihiro Ogawa
      Pages 19-25

  3. Disease and Environment

    1. Front Matter

      Pages 27-27
      Download chapter PDF

    2. Developmental Origins of Nonalcoholic Fatty Liver Disease (NAFLD)

      • Hiroaki Itoh, Naohiro Kanayama
      Pages 29-39

    3. Fetal Origins of Hypertension

      • Yuichiro Arima, Koichi Nishiyama, Yasuhiro Izumiya, Koichi Kaikita, Seiji Hokimoto, Kenichi Tsujita
      Pages 41-48

    4. Involvement of Noncoding RNAs in Stress-Related Neuropsychiatric Diseases Caused by DOHaD Theory

      • Takahiro Nemoto, Yoshihiko Kakinuma
      Pages 49-59

  4. Transgenerational Mechanism and Its Consequences

    1. Front Matter

      Pages 61-61
      Download chapter PDF

    2. Placental Development and Nutritional Environment

      • Kosuke Taniguchi, Tomoko Kawai, Kenichiro Hata
      Pages 63-73

    3. Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm

      • Ryuichi Kimura, Kaichi Yoshizaki, Noriko Osumi
      Pages 75-81

  5. Clinical Significance

    1. Front Matter

      Pages 83-83
      Download chapter PDF

    2. Preemptive Epigenetic Medicine Based on Fetal Programming

      • Takeo Kubota
      Pages 85-95
Back to top

Keywords

About this book

This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.

Editors and Affiliations

  • Faculty of Child Studies, Seitoku University, Matsudo, Japan

    Takeo Kubota

  • Research Organization for Nano & Life Innovation, Waseda University, Tokyo, Japan

    Hideoki Fukuoka

About the editors

Takeo Kubota

Faculty of Child Studies, Seitoku University, Chiba, Japan


Hideoki Fukuoka

Research Institute for Science and Engineering, Waseda University, Tokyo, Japan

Bibliographic Information

  • Book Title: Developmental Origins of Health and Disease (DOHaD)

  • Book Subtitle: From Biological Basis to Clinical Significance

  • Editors: Takeo Kubota, Hideoki Fukuoka

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-10-5526-3

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2018

  • Hardcover ISBN: 978-981-10-5525-6Published: 12 July 2018

  • Softcover ISBN: 978-981-13-3856-4Published: 05 February 2019

  • eBook ISBN: 978-981-10-5526-3Published: 28 June 2018

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VII, 95

  • Number of Illustrations: 7 b/w illustrations, 16 illustrations in colour

  • Topics: Human Physiology, Reproductive Medicine, Developmental Biology

Publish with us

Policies and ethics

Back to top

Search

Navigation