Peptides and Peptide-based Biomaterials and their Biomedical Applications

1. Front Matter

   Pages i-xiii

   PDF

2. Programmable Bio-surfaces for Biomedical Applications

   • Kiyotaka Shiba

   Pages 1-20

3. Solid-Binding Peptides in Biomedicine

   • Andrew Care, Peter L. Bergquist, Anwar Sunna

   Pages 21-36

4. Molecular Modelling of Peptide-Based Materials for Biomedical Applications

   • Tiffany R. Walsh

   Pages 37-50

5. Design Principles of Peptide Based Self-Assembled Nanomaterials

   • Rania S. Seoudi, Adam Mechler

   Pages 51-94

6. Bioprinting and Biofabrication with Peptide and Protein Biomaterials

   • Mitchell Boyd-Moss, Kate Fox, Milan Brandt, David Nisbet, Richard Williams

   Pages 95-129

7. Peptides as Bio-inspired Molecular Electronic Materials

   • John Horsley, Jingxian Yu, Yuan Qi Yeoh, Andrew Abell

   Pages 131-153

8. Peptide-Based Materials for Cartilage Tissue Regeneration

   • Nurcan Hastar, Elif Arslan, Mustafa O. Guler, Ayse B. Tekinay

   Pages 155-166

9. Peptides and Drug Delivery

   • Kavisha R. Ulapane, Brian M. Kopec, Mario E. G. Moral, Teruna J. Siahaan

   Pages 167-184

10. Peptide Lipidation – A Synthetic Strategy to Afford Peptide Based Therapeutics

    • Renata Kowalczyk, Paul W. R. Harris, Geoffrey M. Williams, Sung-Hyun Yang, Margaret A. Brimble

    Pages 185-227

11. Molecular Engineering of Conus Peptides as Therapeutic Leads

    • James T. Daniel, Richard J. Clark

    Pages 229-254

12. Uptake Mechanism of Cell-Penetrating Peptides

    • Maxime Gestin, Moataz Dowaidar, Ülo Langel

    Pages 255-264

13. Empowering the Potential of Cell-Penetrating Peptides for Targeted Intracellular Delivery via Molecular Self-Assembly

    • Yejiao Shi, João Conde, Helena S. Azevedo

    Pages 265-278

14. The Current Role of Cell-Penetrating Peptides in Cancer Therapy

    • Lucia Feni, Ines Neundorf

    Pages 279-295

15. Back Matter

    Pages 297-300

    PDF

Solid-binding peptides have been used increasingly as molecular building blocks in nanobiotechnology as they can direct the assembly and functionalisation of a diverse range of materials and have the ability to regulate the synthesis of nanoparticles and complex nanostructures. Nanostructured materials such as β-sheet fibril-forming peptides and α-helical coiled coil systems have displayed many useful properties including stimulus-responsiveness, modularity and multi-functionality, providing potential technological applications in tissue engineering, antimicrobials, drug delivery and nanoscale electronics. The current situation with respect to self-assembling peptides and bioactive matrices for regenerative medicine are reviewed, as well as peptide-target modeling and an examination of future prospects for peptides in these areas.

• Peptides
• Biopolymers
• Biomedicine
• Nanomaterials
• Biomaterials
• Protein-Ligand Interactions

• Department of Chemistry and Biomolecular Sciences, Macquarie University, North Ryde, Australia

  Anwar Sunna, Peter L. Bergquist

• Biomolecular Discovery and Design, Research Centre, Macquarie University, North Ryde, Australia

  Andrew Care

Anwar Sunna is an Associate Professor in the Department of Chemistry and Biomolecular Sciences at Macquarie University (MQ), Sydney, Australia. He obtained a PhD from the Hamburg University of Technology in Germany. He was manager of the Environmental Biotechnology Co-operative Research Centre at MQ and later was the recipient of the prestigious Vice-Chancellor's Innovation Fellowship. His recent research has been on the interaction between biomolecules and inorganic compounds including new synthetic peptide linkers with applications in the functionalisation of nanoparticles, bioimaging and cancer therapy. Anwar is a member of the MQ Biomolecular Discovery and Design Research Centre, MQ Biosecurity Futures Research Centre, Australian Research Council (ARC) Training Centre for Molecular Technology in the Food Industry and the ARC Centre of Excellence for Nanoscale BioPhotonics. He is also one of the directors of Synthetic Biology Australasia.


Andrew Careis a Research Fellow in the ARC Centre of Excellence for Nanoscale BioPhotonics, a transdisciplinary research centre that aims to develop innovative nanotechnologies to investigate complex living systems. He obtained his PhD from Macquarie University (MQ) in Sydney, Australia. Andrew is also a member of both the MQ Biomolecular Discovery and Design Research Centre and the MQ BioFocus Research Centre. His current research is focused on the development of engineered biomolecules, including solid-binding peptides, to control the self-assembly and biofunctionalisation of materials and biomolecules in a range of biomedical and biotechnological applications.


Peter Bergquist is Emeritus Professor in the Biomolecular Discovery and Design Research Centre at Macquarie University and Emeritus Professor in the Department of Molecular Medicine & Pathology at The University of Auckland Medical School. He has a PhD and DSc from the University of Auckland in New Zealand andhas been a Postdoctoral Fellow and Research Fellow at Harvard Medical School, Yale and Oxford Universities and a Visiting Fellow at New York University School of Medicine. His recent publications reflect research performed with the Environmental Biotechnology Co-operative Research Centre in Australia and he developed research expertise in gas phase catalysis and biofunctionalisation of inorganic matrices containing silica. He has been on the editorial boards of several significant journals such as Applied and Environmental Microbiology and Journal of Bacteriology.

Policies and ethics