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Biomarkers for Endometriosis

State of the Art

  • Book
  • © 2017

Overview

Editors:
  1. Thomas D'Hooghe

    1. Department of Development and Regeneration Organ Systems, Group Biomedical Sciences, KU Leuven (University of Leuven), Leuven, Belgium

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  • Summarizes the latest diagnostic performance of non- or semi-invasive tests for endometriosis

  • Reviews the key current research and developments of biomarkers in related fields

  • Explores the future developments necessary to create a successful non-invasive test for endometriosis

  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. Building Translational Research Infrastructure and Access to Expertise for Biomarker Discovery in Cancer

    • Jacqueline A. Hall
    Pages 1-25

  3. Biomarkers of Endometrial Cancer

    • Nicholas Galazis
    Pages 27-39

  4. Biomarker Development in Chronic Inflammatory Diseases

    • Aristeidis H. Katsanos, Kalliroi Kyriakidi, Fotini B. Karassa, Dimitrios Politis, Alexandros Skamnelos, Dimitrios K. Christodoulou et al.
    Pages 41-75

  5. Endometriosis and Diagnostic Delay: The Patient’s Perspective

    • Silke Apers, Eline A. F. Dancet, Thomas D’Hooghe
    Pages 77-82

  6. Genetic Biomarkers for Endometriosis

    • Sang Hong Lee, Yadav Sapkota, Jenny Fung, Grant W. Montgomery
    Pages 83-93

  7. Epidemiological and Clinical Risk Factors for Endometriosis

    • Leslie V. Farland, Divya K. Shah, Marina Kvaskoff, Krina T. Zondervan, Stacey A. Missmer
    Pages 95-121

  8. Peripheral Blood Biomarkers for Endometriosis

    • Amelie Fassbender, Dorien O, Christian M. Becker, Thomas D’Hooghe
    Pages 123-139

  9. Biomarkers for Endometriosis in Saliva, Urine, and Peritoneal Fluid

    • Ndeye-Aicha Gueye, Jamie Stanhiser, Lindsey Valentine, Alexander Kotlyar, Linnea Goodman, Tommaso Falcone
    Pages 141-163

  10. mRNA and miRNA Biomarkers for Endometriosis

    • Lusine Aghajanova, R. O. Burney, N. D. Tran, Linda C. Giudice
    Pages 165-183

  11. Proteomic Biomarkers for Endometriosis

    • Amelie Fassbender, Antoine Hubert, Etienne Waelkens, Dorien O, Thomas D’Hooghe
    Pages 185-198

  12. Harmonization of Clinical and Laboratory Data to Improve Biomarker Discovery in Endometriosis: WERF EPHect

    • Nilufer Rahmioglu, Amelie Fassbender, Allison Vitonis, Lone Hummelshoj, David Adamson, Christian M. Becker et al.
    Pages 199-226

  13. OMICs Studies and Endometriosis Biomarker Identification

    • Merli Saare, Maire Peters, Alar Aints, Triin Laisk-Podar, Andres Salumets, Signe Altmäe
    Pages 227-258

  14. Back Matter

    Pages 259-267
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Keywords

About this book

This book presents an overview of the diagnostic performance of non- or semi-invasive tests for endometriosis in peripheral blood, endometrium, saliva, peritoneal fluid and urine. The value of existing and emerging systems biology technologies for biomarker development is addressed in several chapters on genetics, microarrays, proteomics and metabolomics. Although tests with high sensitivity and acceptable specificity have been developed, sometimes validated in independent populations and seem promising, more research is needed to translate these data into clinical benefit for patients and coordinate efforts internationally to standarize analysis, reports and operating procedures. The gold standard to diagnose endometriosis is currently through laparoscopic inspection with histological confirmation, a surgical procedure with rare but significant potential risks for the patients. A non-invasive test for endometriosis would be critical for the early detection of endometriosis of symptomatic women with pelvic pain and/or subfertility with normal ultrasound. This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility. Such a test would also be useful in symptomatic women with ultrasound imaging suspicious for endometriosis, since it may be difficult to differentiate an ovarian endometrioma from other ovarian cysts and since the quality of ultrasound imaging is highly variable worldwide.

Editors and Affiliations

  • Department of Development and Regeneration Organ Systems, Group Biomedical Sciences, KU Leuven (University of Leuven), Leuven, Belgium

    Thomas D'Hooghe

About the editor

Thomas M. D’Hooghe is Professor of Reproductive Medicine in the Deparment of  Development and Regeneration of the Biomedical Sciences Group at KU Leuven (University of Leuven), Belgium. Dr. D’Hooghe is also Professor Adjunct, Department of Obstetrics, Gynecology and Reproductive Medicine, Yale University Medical School, New Haven, Connecticut, USA, and Editor-in-Chief of Gynecologic and Obstetric Investigation,Basel, since 2002. Since October 2015, Professor D’Hooghe is the Vice-President and Head of Global Medical Affairs Fertility in the Department of Research and Development at Merck KGaA, Darmstadt, Germany.

Bibliographic Information

  • Book Title: Biomarkers for Endometriosis

  • Book Subtitle: State of the Art

  • Editors: Thomas D'Hooghe

  • DOI: https://doi.org/10.1007/978-3-319-59856-7

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-59854-3Published: 05 October 2017

  • Softcover ISBN: 978-3-319-86719-9Published: 22 August 2018

  • eBook ISBN: 978-3-319-59856-7Published: 22 September 2017

  • Edition Number: 1

  • Number of Pages: XII, 267

  • Number of Illustrations: 5 b/w illustrations, 3 illustrations in colour

  • Topics: Reproductive Medicine, Bioinformatics, Human Genetics

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