Editors:
- The first book to target current research on adamantinomatous craniopharyngiomas (ACPs)
- Topics covered range from pathogenesis to clinical diagnosis to long-term management
- Includes novel and effective treatment approaches
- Includes supplementary material: sn.pub/extras
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Table of contents (10 chapters)
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Front Matter
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Back Matter
About this book
Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underliethe etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.
Editors and Affiliations
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Developmental Biology and Cancer Programme, Birth Defects Research Centre, Institute of Child Health, University College London, London, United Kingdom
Juan Pedro Martinez-Barbera
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Craniofacial Development and Stem Cell Biology, King’s College London, London, United Kingdom
Cynthia Lilian Andoniadou
About the editors
Dr. Cynthia Lilian Andoniadou is a researcher at the Department of Craniofacial Development and Stem Cell Biology of King’s College London focusing on the biology of normal and pathogenic pituitary stem cells.
Bibliographic Information
Book Title: Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma
Editors: Juan Pedro Martinez-Barbera, Cynthia Lilian Andoniadou
DOI: https://doi.org/10.1007/978-3-319-51890-9
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing AG 2017
Hardcover ISBN: 978-3-319-51888-6Published: 03 May 2017
Softcover ISBN: 978-3-319-84770-2Published: 21 July 2018
eBook ISBN: 978-3-319-51890-9Published: 19 April 2017
Edition Number: 1
Number of Pages: XII, 220
Number of Illustrations: 15 b/w illustrations, 32 illustrations in colour
Topics: Endocrinology, Cancer Research, Stem Cells