Overview
- Presents a comprehensive overview of our understanding of ion-beam cancer therapy at the molecular level
- Offers a consistent multiscale approach to the problem of radiation biodamage and its application to ion-beam cancer therapy
- Contributes state-of-the-art knowledge gained by the international community during the COST Action Nano-IBCT (Nanoscale Insights into Ion-Beam Cancer Therapy)
- Includes supplementary material: sn.pub/extras
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Table of contents (14 chapters)
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Front Matter
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Back Matter
Keywords
- COST Action Nano-IBCT
- Collisions and DNA double strand breaks
- Dissociative electron attachment process
- Heavy ion therapy
- Ion-beam cancer therapy
- Irradiation of biological targets with ions
- Multiscale approach to ion-beam cancer therapy
- Proton-beam cancer therapy
- Radiation damage in biological systems
- Radiation dosimetry
- Radiation nanochemistry
- Radiobiological effects with nanoparticles
About this book
This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide.
The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development incancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact.
The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Nanoscale Insights into Ion-Beam Cancer Therapy
Editors: Andrey V. Solov’yov
DOI: https://doi.org/10.1007/978-3-319-43030-0
Publisher: Springer Cham
eBook Packages: Physics and Astronomy, Physics and Astronomy (R0)
Copyright Information: Springer International Publishing Switzerland 2017
Hardcover ISBN: 978-3-319-43028-7Published: 16 December 2016
Softcover ISBN: 978-3-319-82720-9Published: 04 July 2018
eBook ISBN: 978-3-319-43030-0Published: 07 December 2016
Edition Number: 1
Number of Pages: XX, 498
Number of Illustrations: 24 b/w illustrations, 159 illustrations in colour
Topics: Medical and Radiation Physics, Cancer Research, Nanoscale Science and Technology, Nuclear Physics, Heavy Ions, Hadrons, Nanochemistry, Biological and Medical Physics, Biophysics