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Evolutionary Systems Biology

  • Book
  • © 2012

Overview

Editors:
  1. Orkun S. Soyer

    1. University of Exeter, Exeter, United Kingdom

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  • Highlights the diverse array of methodologies and approaches employed in evolutionary systems biology
  • This book tries to decipher “evolutionary design principles” and the origins of systems level properties in biology, such as modularity, robustness, and network connectivity
  • Includes comparative (genomics) analyses that aim to decipher diversity in specific molecular systems
  • Includes supplementary material: sn.pub/extras

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-x
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  2. Evolutionary Systems Biology: Historical and Philosophical Perspectives on an Emerging Synthesis

    • Maureen A. O’Malley
    Pages 1-28

  3. Metabolic Networks and Their Evolution

    • Andreas Wagner
    Pages 29-52

  4. Organization Principles in Genetic Interaction Networks

    • Christopher Jacobs, Daniel Segrè
    Pages 53-78

  5. Evolution of Regulatory Networks: Nematode Vulva Induction as an Example of Developmental Systems Drift

    • Ralf J. Sommer
    Pages 79-91

  6. Life’s Attractors

    • Johannes Jaeger, Anton Crombach
    Pages 93-119

  7. Evolutionary Characteristics of Bacterial Two-Component Systems

    • Xia Sheng, Maxime Huvet, John W. Pinney, Michael P. H. Stumpf
    Pages 121-137

  8. Comparative Interaction Networks: Bridging Genotype to Phenotype

    • Pedro Beltrao, Colm Ryan, Nevan J. Krogan
    Pages 139-156

  9. Evolution In Silico: From Network Structure to Bifurcation Theory

    • Paul François
    Pages 157-182

  10. On the Search for Design Principles in Biological Systems

    • Juan F. Poyatos
    Pages 183-193

  11. Toward a Theory of Multilevel Evolution: Long-Term Information Integration Shapes the Mutational Landscape and Enhances Evolvability

    • Paulien Hogeweg
    Pages 195-224

  12. Evolutionary Principles Underlying Structure and Response Dynamics of Cellular Networks

    • Arno Steinacher, Orkun S. Soyer
    Pages 225-247

  13. Phenotypic Plasticity and Robustness: Evolutionary Stability Theory, Gene Expression Dynamics Model, and Laboratory Experiments

    • Kunihiko Kaneko
    Pages 249-278

  14. Genetic Redundancies and Their Evolutionary Maintenance

    • Jianzhi Zhang
    Pages 279-300

  15. Evolution of Resource and Energy Management in Biologically Realistic Gene Regulatory Network Models

    • Dov J. Stekel, Dafyd J. Jenkins
    Pages 301-328

  16. Reverse Ecology: From Systems to Environments and Back

    • Roie Levy, Elhanan Borenstein
    Pages 329-345

  17. Bacteria–Virus Coevolution

    • Angus Buckling, Michael Brockhurst
    Pages 347-370

  18. The Genotype–Phenotype Maps of Systems Biology and Quantitative Genetics: Distinct and Complementary

    • Christian R. Landry, Scott A. Rifkin
    Pages 371-398

  19. How Evolutionary Systems Biology Will Help Understand Adaptive Landscapes and Distributions of Mutational Effects

    • Laurence Loewe
    Pages 399-410

  20. Building Synthetic Systems to Learn Nature’s Design Principles

    • Eric A. Davidson, Oliver P. F. Windram, Travis S. Bayer
    Pages 411-429
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Keywords

About this book

The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of observed diversity, uncover “evolutionary design principles” and extend predictions made in model organisms to others. In addition, evolutionary systems biology can generate new insights into the adaptive landscape by combining molecular systems biology models and evolutionary simulations. This insight can enable the development of more detailed mechanistic evolutionary hypotheses.

Editors and Affiliations

  • University of Exeter, Exeter, United Kingdom

    Orkun S. Soyer

Bibliographic Information

  • Book Title: Evolutionary Systems Biology

  • Editors: Orkun S. Soyer

  • DOI: https://doi.org/10.1007/978-1-4614-3567-9

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2012

  • Hardcover ISBN: 978-1-4614-3566-2Published: 21 July 2012

  • eBook ISBN: 978-1-4614-3567-9Published: 23 July 2012

  • Edition Number: 1

  • Number of Pages: X, 458

  • Topics: Systems Biology, Evolutionary Biology, Biomedicine general

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