Overview
- Offers a comprehensive review on fundamental concepts and recent advances in the field of amorphous pharmaceuticals
- World-leading specialists from different fields present their perspectives on amorphous drugs
- Introduces to both fundamental physical aspects and preparation and formulation methods
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Table of contents (6 chapters)
Keywords
About this book
This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body.
Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products.
Authors and Affiliations
About the authors
Dr. Marzena Rams-Baron holds an assistant professor position in the Department of Biophysics and Molecular Physics at University of Silesia in Katowice.
Prof. Dr. Renata Jachowicz is currently head of the Chair and Department of Pharmaceutical Technology and Biopharmaceutics at Jagiellonian University in Cracow. She is a member of Committee on Therapy and Drug Research of the Polish Academy of Science, Head of Subcommittee of Pharmaceutical Technology and Biopharmacy and also Head of the Expert Group of Pharmaceutical Technology and Galens Products of Polish Pharmacopoeia Committee.
Prof. Dr. Elena Boldyreva is a Chief Researcher at the Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of Russian Academy of Sciences in Novosibirsk and the Head of the Chair of Solid State Chemistry of Novosibirsk State University.Dr. Deliang Zhou is a principal research pharmaceutical scientist in Drug Products, Operations Science & Technology at AbbVie.
Dr. Witold Jamróz holds an assistant professor position in the Department of Pharmaceutical Technology and Biopharmaceutics at Jagiellonian University in Cracow
Prof. Dr. Marian Paluch is currently the head of the Department of Biophysics and Molecular Physics at University of Silesia in Katowice. Since 2010 he is an academic editor in AIP Advances. He is (co)author of more than 380 publications, a book and several book chapters. His papers were cited more than 7700 times.
Bibliographic Information
Book Title: Amorphous Drugs
Book Subtitle: Benefits and Challenges
Authors: Marzena Rams-Baron, Renata Jachowicz, Elena Boldyreva, Deliang Zhou, Witold Jamroz, Marian Paluch
DOI: https://doi.org/10.1007/978-3-319-72002-9
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer International Publishing AG 2018
Hardcover ISBN: 978-3-319-72001-2Published: 20 February 2018
Softcover ISBN: 978-3-319-89129-3Published: 06 June 2019
eBook ISBN: 978-3-319-72002-9Published: 09 February 2018
Edition Number: 1
Number of Pages: IX, 230
Number of Illustrations: 21 b/w illustrations, 48 illustrations in colour
Topics: Medicinal Chemistry, Pharmaceutical Sciences/Technology, Phase Transitions and Multiphase Systems, Thermodynamics, Ceramics, Glass, Composites, Natural Materials, Biomedical Engineering and Bioengineering