Progressive Multiple Sclerosis

1. Front Matter

   Pages i-ix

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2. General Introduction: What Is Progressive Multiple Sclerosis?

   • Alastair Wilkins, Stanley Hawkins

   Pages 1-29

3. Epidemiology of Progressive Multiple Sclerosis

   • Katharine Harding, Neil Robertson

   Pages 31-47

4. The Neuropathology of Progressive Multiple Sclerosis

   • Nikos Evangelou, Simon M. L. Paine, Emma C. Tallantyre

   Pages 49-69

5. Mechanisms of Disease Progression

   • Alastair Wilkins

   Pages 71-92

6. Imaging Disease Progression

   • Declan Chard, Olga Ciccarelli

   Pages 93-121

7. Biomarkers of Disease Progression

   • Axel Petzold

   Pages 123-154

8. Symptomatic Treatment for Progressive Multiple Sclerosis

   • Steven M. Bailey, Claire M. Rice

   Pages 155-205

9. Trials of Licenced RRMS DMTs in Progressive MS

   • Michael Hutchinson, David P. J. Hunt

   Pages 207-232

10. Trials of Novel Therapies Specifically for Progressive MS

    • R. S. Nicholas, A. Nandoskar, M. Hutchinson, T. Friede

    Pages 233-252

11. Rehabilitation in People with Progressive MS

    • Jennifer Freeman

    Pages 253-274

12. Future Therapies for Progressive Multiple Sclerosis

    • Neil Scolding

    Pages 275-300

13. Back Matter

    Pages 301-307

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This revised, updated second edition draws together the basic science, pathology, epidemiology and treatment possibilities in progressive multiple sclerosis. Each chapter addresses specific aspects of progressive multiple sclerosis providing an extensive review of the current literature and a discussion of the likely mechanisms of tissue injury relevant to the disease. New additions to the second edition include a description of clinical scales used to determine levels of disability; recent trials specifically directed at reducing disease progression; rehabilitation; and an in depth discussion of the similarities and differences between primary and secondary multiple sclerosis.

The biological processes underlying disease progression are elucidated as are specific pathophysiological mechanisms. The basic science of axonal degeneration and the clinical understanding of progressive multiple sclerosis are discussed in the context of emerging and future therapies for disease progression as are trials which have been and will be conducted for progressive multiple sclerosis. An overview of biomarkers for the disease is included and existing symptomatic therapies for progressive multiple sclerosis are covered in detail.

Progressive Multiple Sclerosis, Second Edition is ideal for both general neurologists and those with a specialist interest in multiple sclerosis. It will also be of interest to neurologists in training and other medical professionals treating this common disease.

• multiple sclerosis biomarkers
• MS
• multiple sclerosis epidemiology
• Multiple Sclerosis
• multiple sclerosis pathophysiology
• Progressive multiple sclerosis
• multiple sclerosis therapy
• multiple sclerosis clinical scale
• axonal injury

“This book would be most useful to general neurologists and neurology residents, as they would be most likely to care for patients with progressive multiple sclerosis. The book meets the needs of the intended audience … . This is a useful and needed book that concisely summarizes recent clinical trial data on new treatments for progressive multiple sclerosis. There are not many books that address this and therefore neurologists will find this one a useful addition to their library.” (Rashmi B. Halker Singh, Doody's Book Reviews, March, 2018)

• Southmead Hospital, University of Bristol, Bristol, United Kingdom

  Alastair Wilkins

Dr Alastair Wilkins (BA, MB,BChir, PhD(Cantab)) is Reader in Neurology, University of Bristol, and Consultant Neurologist at Southmead Hospital, Bristol, UK. He researches axonal injury in multiple sclerosis and related disorders.

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