Zika in Focus

1. Front Matter

   Pages i-vi

   PDF

2. Zika Virus: An Overview

   • Maria de Fátima Viana Vasco Aragão, Arthur Cesário de Holanda, Luziany Carvalho Araújo, Marcelo Moraes Valença

   Pages 1-7

3. Zika Virus: History and Infectology

   • Carlos Alexandre Antunes de Brito

   Pages 9-32

4. Congenital Zika Syndrome: Clinical Aspects

   • Vanessa van der Linden, Epitacio Leite Rolim Filho, Ana van der Linden

   Pages 33-45

5. Ocular Findings in Children with Congenital Zika Syndrome

   • Camila V. Ventura, Natalia C. Dias, Audina M. Berrocal, Liana O. Ventura

   Pages 47-57

6. Zika Virus: Laboratory Diagnosis

   • Marli Tenório Cordeiro

   Pages 59-62

7. Neuroimaging Findings of Congenital Zika Syndrome

   • Maria de Fátima Viana Vasco Aragão, Alessandra Mertens Brainer-Lima, Arthur Cesário de Holanda, Natacha Calheiros de Lima Petribu

   Pages 63-92

8. Radiological Differential Diagnosis of Microcephaly

   • Natacha Calheiros de Lima Petribu, Maria de Fátima Viana Vasco Aragão

   Pages 93-105

9. Cases: Spectrum of Computed Tomography in Congenital Zika Syndrome

   • Natacha Calheiros de Lima Petribu, Maria de Fátima Viana Vasco Aragão

   Pages 107-124

10. Cases: Spectrum of Magnetic Resonance Imaging in Congenital Zika Syndrome

    • Alessandra Mertens Brainer-Lima, Maria de Fátima Viana Vasco Aragão, Arthur Cesário de Holanda

    Pages 125-137

11. Histopathological Findings of Congenital Zika Syndrome

    • Arthur Cesário de Holanda, Roberto José Vieira de Mello

    Pages 139-150

12. Back Matter

    Pages 151-156

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This book addresses the most important postnatal features of Zika virus infection, providing important information on its epidemiology, pathology, clinical aspects, imaging and laboratory diagnosis. Since the report of a Zika virus infection epidemic in Northeastern Brazil in 2015, the world has paid close attention to this emergent disease. Historically, this has been the third outbreak of Zika infection described (preceded by outbreaks in Micronesia and French Polynesia), but for the first time the association with congenital microcephaly and other neurological co-morbidities in infants from women infected with the Zika virus was observed. Since then, government bodies, public health agencies, medical societies and scholars have joined forces to understand this disease, and to promote its prevention and management.
Currently, the relationship between Zika virus and microcephaly is well established, as well as the most characteristic findings of congenital Zika syndrome (e.g. microcephaly, arthrogryposis, ophthalmologic and hearing abnormalities). Also, the spectrum of the disease’s severity has broadened, with less severe cases (without microcephaly) being recently recognized. Even so, there is currently a dearth of material on Zika virus infection for healthcare professional around the world.
Addressing that gap, Zika In Focus – Postnatal Aspects aims to help the medical community worldwide by presenting the most important features of Zika virus infection from a postnatal perspective. It is intended to all professionals and researchers interested in this condition, especially paediatricians, radiologists and neurologists, offering them a practical guide to recognizing congenital Zika syndrome in its many aspects and focusing on the radiological pattern of lesions that can be found from the mild to the most severe cases.

• Zika virus
• Microcephaly
• Arthrogryposis
• Calcification
• Calcifications
• Malformation
• Malformations
• Cortical development
• infectious diseases

“The purpose is to provide the most current references on the clinical aspects of this viral disease and its effect on children. … The book certainly meets this goal. The audience is healthcare providers of women and children. However, it will also be of interest to radiologists and public health administrators.” (Jay P. Goldsmith, Doody’s Book Reviews, April, 2017)

• Centro Diagnóstico Multimagem, Mauricio de Nassau University, Recife, Brazil

  Maria de Fátima Viana Vasco Aragão

Maria de Fátima Viana Vasco Aragão is a Professor of Radiology at the Maurício de Nassau University and scientific director of the Multimagem Diagnostic Centre in Recife, Brazil. She received her medical degree from the Federal University of Pernambuco in 1987 and completed her residency in radiology at Ribeirão Preto Faculty of Medicine, University of São Paulo, Brazil. She completed fellowships in CT, MRI and neuroradiology at Med Imagem Beneficencia Portuguesa, São Paulo, Brazil, and later at Mount Sinai Hospital Center in New York, USA. In 2010 she received her PhD in Neuroscience from the Federal University of Pernambuco in Recife. She is a founding member of the Brazilian Society of Neuroradiology, full member of the Brazilian College of Radiology and a member of the American Society of Neuroradiology, the European Society of Radiology and the Radiological Society of North America. She served as president of the Pernambuco Radiology Society from 2014 to 2016, being recently re-elected for 2016 to 2018.

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