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The Hippo Signaling Pathway and Cancer

  • Book
  • © 2013

Overview

Editors:
  1. Moshe Oren

    1. , Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

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  2. Yael Aylon

    1. , Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Explores virtually all aspects of tumor biology in relation to the
  • Gathers wide-ranging and burgeoning information into an accessible format
  • Features timely research from leading scientists in the field
  • Includes supplementary material: sn.pub/extras

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-vi
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  2. Introduction

    • Moshe Oren, Yael Aylon
    Pages 1-8

  3. Up-stream Components of Hippo Signaling

    1. Front Matter

      Pages 9-9
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    2. Merlin and Angiomotin in Hippo-Yap Signaling

      • Chunling Yi, Joseph Kissil
      Pages 11-25

    3. MST1/2 and Other Upstream Signaling that Affect Hippo Pathway Function

      • Julien Fitamant, Dawang Zhou, Fan Mou, Laura Regué Barrufet, Nabeel Bardeesy, Joseph Avruch
      Pages 27-49

  4. YAP and TAZ

    1. Front Matter

      Pages 51-51
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    2. YAP1 Uses Its Modular Protein Domains and Conserved Sequence Motifs to Orchestrate Diverse Repertoires of Signaling

      • Marius Sudol, Irwin H. Gelman, Jianmin Zhang
      Pages 53-70

    3. Regulation of YAP and TAZ Transcription Co-activators

      • Fa-Xing Yu, Bin Zhao, Kun-Liang Guan
      Pages 71-87

    4. Regulation of YAP and TAZ by Epithelial Plasticity

      • Stefano Piccolo, Michelangelo Cordenonsi
      Pages 89-113

  5. Apoptosis and Hippo Signaling

    1. Front Matter

      Pages 115-115
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    2. Hippo Pathway and Apoptosis

      • Garth Hamilton, Eric O’Neill
      Pages 117-145

    3. YAP and p73: A Matter of Mutual Specificity in Tumor Suppression

      • Sara Donzelli, Sabrina Strano, Giovanni Blandino
      Pages 147-172

    4. The c-Abl/YAP/p73 Apoptotic Module and the HIPPO Pathway

      • Nina Reuven, Yosef Shaul
      Pages 173-195

  6. Cell Cycle and Hippo Signaling

    1. Front Matter

      Pages 197-197
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    2. Hippo in Cell Cycle and Mitosis

      • Norikazu Yabuta, Hiroshi Nojima
      Pages 199-221

  7. Mouse Models

    1. Front Matter

      Pages 223-223
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    2. Hippo and Mouse Models for Cancer

      • Min-Chul Kim, Tae-Shin Kim, Tackhoon Kim, Dae-Sik Lim
      Pages 225-247

    3. Roles of Hippo Signaling During Mouse Embryogenesis

      • Hiroshi Sasaki
      Pages 249-264

    4. Hippo Signaling and Stem Cells

      • Kriti Shrestha, Fernando D. Camargo
      Pages 265-279

    5. Hippo Signaling and Organ Size Control

      • Randy L. Johnson
      Pages 281-291
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Keywords

About this book

​​The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorigenesis, and many leading scientists are showing increased interest in this growing field and it's relation to cancer.  The chapters in this volume cover virtually all aspects of tumor biology, because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Ras, Wnt, TGFbeta and p53. Moreover, Hippo signaling is not solely involved in regulating “classic” tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. The primary audience are researchers interested in basic science in the areas of tumor suppression, cell cycle and size regulation, development and differentiation. 

Editors and Affiliations

  • , Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

    Moshe Oren, Yael Aylon

About the editors

Dr. Moshe Oren has been investigating the molecular biology of cancer-related processes for years, with particular emphasis on the p53 tumor suppressor and its associated network of proteins and genes. Dr. Oren has cloned he p53 gene when he was a post doc working under Dr. Arnold Levine. He has acted as a member of several international research consortia, as well as co-organizer of numberous national and international conferences. Dr. Oren has won several cancer research awards and his most recent achievement includes serving as President Elect of the European Association for Cancer Research in 2010. He serves on several editorial boards including Molecular Cell, EMBO Journal, Molecular and Cellular Biology, Molecular Carcinogenesis, and Molecular Oncology, to name a few.

Dr. Yael Aylon is a research associate in Dr. Oren's lab at the Weizmann Institute and has been invited to speak at several international conferences and seminar.

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