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  • Book
  • © 2007

Biopacemaking

  • Topics are presented missed so far in literature as well as recent scientific breakthroughs

Part of the book series: Series in Biomedical Engineering (BIOMENG)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-VIII
  2. Biopacemaking: Clinically Attractive, Scientifically a Challenge

    • Jacques M. T. de Bakker, Antonio Zaza
    Pages 1-5
  3. Creating a Cardiac Pacemaker by Gene Therapy

    • Traian M. Anghel, Steven M. Pogwizd
    Pages 45-62
  4. Biological Pacemakers Based on If

    • Michael R. Rosen, Peter R. Brink, Ira S. Cohen, Richard B. Robinson
    Pages 63-78
  5. Gene Therapy to Create Biological Pacemakers

    • Gerard J. J. Boink, Jurgen Seppen, Jacques M. T. de Bakker, Hanno L. Tan
    Pages 79-93
  6. Inhibition of Cardiomyocyte Automaticity by Electrotonic Application of Inward Rectifier Current from Kir2.1 Expressing Cells

    • Teun P. de Boer, Toon A. B. van Veen, Marien J. C. Houtman, John A. Jansen, Shirley C. M. van Amersfoorth, Pieter A. Doevendans et al.
    Pages 94-104
  7. Propagation of Pacemaker Activity

    • Ronald W. Joyner, Ronald Wilders, Mary B. Wagner
    Pages 105-120
  8. Computer Modelling of the Sinoatrial Node

    • Ronald Wilders
    Pages 121-148
  9. Application of Mesenchymal Stem Cell-Derived Cardiomyocytes as Bio-pacemakers: Current Status and Problems to Be Solved

    • Yuichi Tomita, Shinji Makino, Daihiko Hakuno, Naoichiro Hattan, Kensuke Kimura, Shunichiro Miyoshi et al.
    Pages 149-167
  10. Enrichment of Cardiac Pacemaker-Like Cells: Neure gulin-1 and Cyclic amp Increase If-Current Density and Connexin 40 mRNA Levels in Fetal Cardiomyocytes

    • Arjang Ruhparwar, Fikret Er, Ulrich Martin, Kristin Radke, Ina Gruh, Michael Niehaus et al.
    Pages 168-177
  11. Back Matter

    Pages 179-182

About this book

The development of a bio-engineered pacemaker is of substantial clinical and also scientific interest because it promises to overcome several limitations of electronic pacemakers. Moreover it may answer the longstanding question of whether the complex structure of the sinus node is indeed a prerequisite for reliable pacemaking, or simpler structures might work as well.

This book gives an overview of the current state-of-the-art of creating a bio-engineered pacemaker. It shows the approaches to develop of genetic and cell-based engineering methods suitable to implement them with safety and stability. It also illuminates the problems that need to be solved before bio-pacemaking can be considered for clinical use.

Editors and Affiliations

  • Academic Medical Center, Amsterdam, The Netherlands

    J. A. E Spaan

  • Department of Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands

    Ruben Coronel

  • Department of Experimental Cardiology Center for Heart Failure Research, Academic Medical Center, Amsterdam

    Jacques M. T. Bakker

  • The Heart Lung Center, University Medical Center, Utrecht

    Jacques M. T. Bakker

  • The Interuniversity Cardiology, Institute of the Netherlands, Utrecht, The Netherlands

    Jacques M. T. Bakker

  • Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Milano, Italy

    Antonio Zaza

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access