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Evolution by Gene Duplication

  • Book
  • © 1970

Overview

Authors:
  1. Susumu Ohno

    1. Department of Biology, City of Hope Medical Center, Duarte, USA

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Table of contents (22 chapters)

  1. Front Matter

    Pages I-XV
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  2. Introduction

    1. Introduction

      • Susumu Ohno
      Pages 1-2

  3. The Creation of Life Based on the Inherent Complementality between Purine and Pyrimidine Bases

    1. Front Matter

      Pages 3-3
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    2. Perpetuation of the Germ Line

      • Susumu Ohno
      Pages 3-4

    3. Replication of Nucleic Acids on the Basis of A-T, G-C Complementality and the Origin of Life

      • Susumu Ohno
      Pages 4-15

    4. Chromosomes of Eukaryotes

      • Susumu Ohno
      Pages 15-20

  4. Mutation and the Conservative Nature of Natural Selection

    1. Front Matter

      Pages 21-21
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    2. Mutation as a Change in the Base Sequence of a DNA Cistron

      • Susumu Ohno
      Pages 21-26

    3. Forbidden Mutations

      • Susumu Ohno
      Pages 26-32

    4. Tolerable Mutations

      • Susumu Ohno
      Pages 32-40

    5. The Conservative Nature of Chromosomal Evolution

      • Susumu Ohno
      Pages 41-47

    6. The Spontaneous Mutation Rate

      • Susumu Ohno
      Pages 48-55

    7. The Rate of Evolution and the Importance of Isolation

      • Susumu Ohno
      Pages 55-58

  6. Mechanisms of Gene Duplication

    1. Front Matter

      Pages 89-89
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Keywords

About this book

It is said that "necessity is the mother of invention". To be sure, wheels and pulleys were invented out of necessity by the tenacious minds of upright citi­ zens. Looking at the history of mankind, however, one has to add that "Ieisure is the mother of cultural improvement". Man's creative genius flourished only when his mind, freed from the worry of daily toils, was permitted to entertain apparently useless thoughts. In the same manner, one might say with regard to evolution that "natural selection mere(y tnodifted, while redundanry created". Natural selection has been extremely effective in policing alleHe mutations which arise in already existing gene loci. Because of natural selection, organisms have been able to adapt to changing environments, and by adaptive radiation many new species were created from a common ancestral form. Y et, being an effective policeman, natural selection is extremely conservative by nature. Had evolution been entirely dependent upon natural selection, from a bacterium only numerous forms of bacteria would have emerged. The creation of metazoans, vertebrates and finally mammals from unicellular organisms would have been quite impos­ sible, for such big leaps in evolution required the creation of new gene loci with previously nonexistent functions. Only the cistron which became redun­ dant was able to escape from the relentless pressure of natural selection, and by escaping, it accumulated formerly forbidden mutations to emerge as a new gene locus.

Authors and Affiliations

  • Department of Biology, City of Hope Medical Center, Duarte, USA

    Susumu Ohno

Bibliographic Information

  • Book Title: Evolution by Gene Duplication

  • Authors: Susumu Ohno

  • DOI: https://doi.org/10.1007/978-3-642-86659-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1970

  • Softcover ISBN: 978-3-642-86661-6Published: 23 August 2014

  • eBook ISBN: 978-3-642-86659-3Published: 11 December 2013

  • Edition Number: 1

  • Number of Pages: XV, 160

  • Number of Illustrations: 20 b/w illustrations

  • Topics: Medicine/Public Health, general

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