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RNA Processing

Disease and Genome-wide Probing

  • Book
  • © 2016

Overview

Editors:
  1. Gene W. Yeo

    1. Dept of Cellular and Molecular Medicine, Institute for Genomic Medicine, La Jolla, USA

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  • The first book focused on genome-wide and systems-level perspectives on the diverse roles that RNA binding proteins play in development and disease
  • Authored by leading experts in the field
  • Looks at potential new areas of research on post-transcriptional gene regulation
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 907)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Experimental and Computational Considerations in the Study of RNA-Binding Protein-RNA Interactions

    • Eric L. Van Nostrand, Stephanie C. Huelga, Gene W. Yeo
    Pages 1-28

  3. Genome-Wide Approaches for RNA Structure Probing

    • Ian M. Silverman, Nathan D. Berkowitz, Sager J. Gosai, Brian D. Gregory
    Pages 29-59

  4. Tethered Function Assays as Tools to Elucidate the Molecular Roles of RNA-Binding Proteins

    • Tomas J. Bos, Julia K. Nussbacher, Stefan Aigner, Gene W. Yeo
    Pages 61-88

  5. Single Molecule Approaches in RNA-Protein Interactions

    • Victor Serebrov, Melissa J. Moore
    Pages 89-106

  6. RNA Dynamics in the Control of Circadian Rhythm

    • Giorgia Benegiamo, Steven A. Brown, Satchidananda Panda
    Pages 107-122

  7. Roles of RNA-binding Proteins and Post-transcriptional Regulation in Driving Male Germ Cell Development in the Mouse

    • Donny D. Licatalosi
    Pages 123-151

  8. Regulation of Stem Cell Self-Renewal and Oncogenesis by RNA-Binding Proteins

    • Ayuna Hattori, Kristina Buac, Takahiro Ito
    Pages 153-188

  9. Controlling the Editor: The Many Roles of RNA-Binding Proteins in Regulating A-to-I RNA Editing

    • Michael C. Washburn, Heather A. Hundley
    Pages 189-213

  10. Splicing Factor Mutations in Cancer

    • Rafael Bejar
    Pages 215-228

  11. Regulation of Tissue-Specific Alternative Splicing: C. elegans as a Model System

    • Xicotencatl Gracida, Adam D. Norris, John A. Calarco
    Pages 229-261

  12. RNA Granules and Diseases: A Case Study of Stress Granules in ALS and FTLD

    • Alexander C. Fan, Anthony K. L. Leung
    Pages 263-296

  13. Post-Translational Modifications and RNA-Binding Proteins

    • Michael T. Lovci, Mario H. Bengtson, Katlin B. Massirer
    Pages 297-317

  14. Back Matter

    Pages 319-326
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Keywords

About this book

Ribonucleic acid (RNA) binding proteins currently number in the thousands and defects in their function are at the heart of diseases such as cancer and neurodegeneration.  RNA binding proteins have become implicated in the intricate control of surprisingly diverse biological settings, such as circadian rhythm, stem cell self-renewal, oncogenesis and germ cell development. This book surveys a range of genome-wide and systems approaches to studying RNA binding proteins, the importance of RNA binding proteins in development, cancer and circadian rhythm. 
   





Editors and Affiliations

  • Dept of Cellular and Molecular Medicine, Institute for Genomic Medicine, La Jolla, USA

    Gene W. Yeo

About the editor

Dr. Gene Yeo is a scientist, entrepreneur, inventor and expert in the area of RNA, genomics and neurological diseases.  Dr. Yeo obtained his BS in Chemical Engineering and a BA in Economics from the University of Illinois, Urbana-Champaign. He has a MA in Business Administration from the Rady School of Management at the University of California, San Diego (UCSD).  Dr. Yeo earned his Ph.D. in Computational Neuroscience from the Massachusetts Institute of Technology.  Using comparative genomics and statistical learning theory Dr. Yeo pioneered new computational approaches to attack the problem of splicing and splicing-mediated gene regulation.  In 2008, Dr. Yeo was appointed an Assistant Professor in the Department of Cellular and Molecular Medicine at UCSD.  In 2011, Dr. Yeo was awarded the Alfred P Sloan Fellowship in recognition of his work in computational molecular biology. Dr. Yeo is also an Adjunct Professor at the National University of Singapore and avisiting researcher at the Molecular Engineering Laboratory under Nobel Laureate Sydney Brenner’s auspices.


Bibliographic Information

  • Book Title: RNA Processing

  • Book Subtitle: Disease and Genome-wide Probing

  • Editors: Gene W. Yeo

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-29073-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016

  • Hardcover ISBN: 978-3-319-29071-3Published: 09 June 2016

  • Softcover ISBN: 978-3-319-80484-2Published: 30 May 2018

  • eBook ISBN: 978-3-319-29073-7Published: 02 June 2016

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 326

  • Number of Illustrations: 3 b/w illustrations, 34 illustrations in colour

  • Topics: Human Genetics

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