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Preventive and Predictive Genetics: Towards Personalised Medicine

  • Book
  • © 2015

Overview

Editors:
  1. Godfrey Grech

    1. Pathology Department, University of Malta, Msida, Malta

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    You can also search for this editor in PubMed   Google Scholar

  2. Iris Grossman

    1. IsraGene, Yakir, Israel

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Current knowledge on Pharmacogenetics and its central role to Personalised Medicine
  • Part of EPMA Book Series on PPPM aspects
  • Well recognised authors contribute to the book
  • Can be used as textbook for Masters classes
  • Recommendations and future outlook is included
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine (APPPM, volume 9)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xx
    Download chapter PDF

  2. Introduction

    • Godfrey Grech, Iris Grossman
    Pages 1-6

  3. Preventive and Predictive Genetics: A perspective

    • Godfrey Grech, Christian Scerri, Jeanesse Scerri, Tomris Cesuroglu
    Pages 7-41

  4. Roadmap to Drug Development Enabled by Pharmacogenetics

    • James P. Bishop, Sonal B. Halburnt, Patrick A. Akkari, Scott Sundseth, Iris Grossman
    Pages 43-67

  5. Pharmacogenetics—Statistical Considerations

    • Aiden Flynn, Craig Ledgerwood, Caroline O’Hare
    Pages 69-89

  6. Pharmacokinetics and Pharmacogenetics: Bringing the Magic Bullet Closer to Reality

    • Janet Mifsud, Marc Maliepaard
    Pages 91-107

  7. Pharmacogenetics of Adverse Drug Reactions

    • Richard Myles Turner, Munir Pirmohamed
    Pages 109-156

  8. Pharmacogenomics for Haemoglobinopathies Therapeutics

    • Aikaterini Gravia, Vasiliki Chondrou, Theodora Katsila, George P. Patrinos
    Pages 157-171

  9. Pharmacogenetics of Neurodegenerative Disorders

    • Ramón Cacabelos, Clara Torrellas, Pablo Cacabelos, María J. Villanueva, Sergio Piñeiro, Cristina Solveira
    Pages 173-240

  10. Pharmacogenetics of Asthma

    • Anthony G. Fenech, Ian Sayers, Michael A. Portelli
    Pages 241-274

  11. Pharmacogenetics and Antineoplastic Therapies

    • Jai N. Patel, Christine M. Walko, Federico Innocenti
    Pages 275-305

  12. Pharmacogenetics of Coumarin Anticoagulant Therapy

    • Rianne M.F. van Schie, Talitha I. Verhoef, Anthonius de Boer, Felix J.M. van der Meer, William K. Redekop, Tom Schalekamp et al.
    Pages 307-328

  13. Implementation of Genomic Medicine: Tools and Challenges

    • Godfrey Grech, Ron van Schaik, Joseph Borg
    Pages 329-347

  14. Ethical Considerations in the Genomic Era

    • Bridget Ellul
    Pages 349-375

  15. Back Matter

    Pages 377-378
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Keywords

About this book

Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data.  Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Editors and Affiliations

  • Pathology Department, University of Malta, Msida, Malta

    Godfrey Grech

  • IsraGene, Yakir, Israel

    Iris Grossman

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