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Subcellular Biochemistry

Creatine and Creatine Kinase in Health and Disease

Herausgeber: Salomons, Gajja S., Wyss, Markus (Eds.)

  • A key reference summarizing the state-of-the-art in creatine and creatine kinase research
  • An authoritative volume compiled by outstanding experts in the field
  • A must-read for understanding the links between creatine metabolism and neuroprotection as well as neurodegenerative disease
  • Aims to lay the foundation for the next boost in research on the pleiotropic functions of creatine and creatine kinase
  • The text sets the stage for systems biology of creatine and creatine kinase
Weitere Vorteile

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eBook 190,39 €
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  • ISBN 978-1-4020-6486-9
  • Versehen mit digitalem Wasserzeichen, DRM-frei
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Hardcover 246,10 €
Preis für Deutschland (Brutto)
  • ISBN 978-1-4020-6485-2
  • Kostenfreier Versand für Individualkunden weltweit
  • Gewöhnlich versandfertig in 3-5 Werktagen.
Softcover 246,10 €
Preis für Deutschland (Brutto)
  • ISBN 978-90-481-7652-6
  • Kostenfreier Versand für Individualkunden weltweit
  • Gewöhnlich versandfertig in 3-5 Werktagen.
Über dieses Buch

Although creatine was discovered already in the 1830s, it is only in recent years that its crucial role for human health and general well-being has been increasingly realized and appreciated. A number of beneficial health effects have been ascribed to oral creatine supplementation, such as neuroprotective, ergogenic, anti-diabetic, anti-inflammatory, antiviral, or antitumor effects. Creatine may even improve memory and intelligence. In the present book, emphasis is placed on the intricate interplay between creatine and creatine kinase function on one hand, and proper brain function, neurodegenerative disease and/or neuroprotection on the other hand. The book also elaborates on the recently identified inborn errors of creatine biosynthesis and transport, the so-called cerebral creatine deficiency syndromes. The clinical hallmarks of these disorders are mental retardation, epilepsy, autistic-like behaviour, and speech and language delay. In addition, the muscle growth- and strength-promoting effects, the pharmacokinetics and the safety of oral creatine supplementation are discussed. Finally, the present book outlines the emerging "systems biology" approaches for understanding the pleiotropic effects of creatine and creatine kinase, and hypothesizes on the most promising and influential future avenues of research towards creatine-based nutritional strategies for the prevention of neurological disease, and for improving the quality of life in general.

Inhaltsverzeichnis (16 Kapitel)

  • Introduction – Creatine: Cheap Ergogenic Supplement with Great Potential for Health and Disease

    Wallimann, Theo

    Seiten 1-16

  • Early Evolution of the Creatine Kinase Gene Family and the Capacity for Creatine Biosynthesis and Membrane Transport

    Ellington, W. Ross (et al.)

    Seiten 17-26

  • The Creatine Kinase Phosphotransfer Network: Thermodynamic and Kinetic Considerations, the Impact of the Mitochondrial Outer Membrane and Modelling Approaches

    Saks, Valdur (et al.)

    Seiten 27-65

  • Expression and Function of Agat, Gamt and CT1 in the Mammalian Brain

    Braissant, Olivier (et al.)

    Seiten 67-81

  • A Novel Relationship Between Creatine Transport at the Blood-Brain and Blood-Retinal Barriers, Creatine Biosynthesis, And its Use for Brain and Retinal Energy Homeostasis

    Tachikawa, Masanori (et al.)

    Seiten 83-98

Dieses Buch kaufen

eBook 190,39 €
Preis für Deutschland (Brutto)
  • ISBN 978-1-4020-6486-9
  • Versehen mit digitalem Wasserzeichen, DRM-frei
  • Erhältliche Formate: PDF
  • eBooks sind auf allen Endgeräten nutzbar
  • Sofortiger eBook Download nach Kauf
Hardcover 246,10 €
Preis für Deutschland (Brutto)
  • ISBN 978-1-4020-6485-2
  • Kostenfreier Versand für Individualkunden weltweit
  • Gewöhnlich versandfertig in 3-5 Werktagen.
Softcover 246,10 €
Preis für Deutschland (Brutto)
  • ISBN 978-90-481-7652-6
  • Kostenfreier Versand für Individualkunden weltweit
  • Gewöhnlich versandfertig in 3-5 Werktagen.
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Bibliografische Information

Bibliographic Information
Buchtitel
Creatine and Creatine Kinase in Health and Disease
Herausgeber
  • Gajja S. Salomons
  • Markus Wyss
Titel der Buchreihe
Subcellular Biochemistry
Buchreihen Band
46
Copyright
2007
Verlag
Springer Netherlands
Copyright Inhaber
Springer Science+Business Media B.V.
eBook ISBN
978-1-4020-6486-9
DOI
10.1007/978-1-4020-6486-9
Hardcover ISBN
978-1-4020-6485-2
Softcover ISBN
978-90-481-7652-6
Buchreihen ISSN
0306-0225
Auflage
1
Seitenzahl
XVIII, 354
Themen