Advances in Experimental Medicine and Biology

Mitochondrial DNA and Diseases

Editors: Sun, Hongzhi, Wang, Xiangdong (Eds.)

  • Introduces the basic information of mtDNA
  • Summarize the latest development of mtDNA and disease
  • Focus on mtDNA biology and the roles of mtDNA in disease 
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eBook 130,89 €
price for China (P.R.) (gross)
  • ISBN 978-981-10-6674-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 154,99 €
price for China (P.R.) (gross)
  • ISBN 978-981-10-6673-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing.  Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.

About the authors

Dr. Hongzhi Sun is Professor and President of Jinzhou Hospital, Jinzhou Medical University, Jinzhou, Liaoning Province, China.

Dr. Xiangdong Wang is Distinguished Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Executive Director of Clinical Science Institute of Fudan University Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.

Table of contents (4 chapters)

  • The Role of DNA Repair in Maintaining Mitochondrial DNA Stability

    Linlin Zhang, Aurelio Reyes, Xiangdong Wang

    Pages

    Preview Buy Chapter 24,95 €
  • Epithelial Mitochondrial Dysfunction in Lung Disease

    Linlin Zhang, et al.

    Pages

    Preview Buy Chapter 24,95 €
  • Roles of Mitochondrial DNA in Energy Metabolism

    Jiapei Lv, Madhav Bhatia, Xiangdong Wang

    Pages

    Preview Buy Chapter 24,95 €
  • Metabolic Regulation in Mitochondria and Drug Resistance

    Yue Pan, et al.

    Pages

    Preview Buy Chapter 24,95 €

Buy this book

eBook 130,89 €
price for China (P.R.) (gross)
  • ISBN 978-981-10-6674-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 154,99 €
price for China (P.R.) (gross)
  • ISBN 978-981-10-6673-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Mitochondrial DNA and Diseases
Editors
  • Hongzhi Sun
  • Xiangdong Wang
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1038
Copyright
2017
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-6674-0
DOI
10.1007/978-981-10-6674-0
Hardcover ISBN
978-981-10-6673-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VII, 230
Number of Illustrations and Tables
27 b/w illustrations, 62 illustrations in colour
Topics