Biomaterials Associated Infection

Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function.  These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.

• Anti-adhesive and Antibacterial Polymer Brushes
• Anti-adhesive and Antibacterial  Polymer Brushes
• Anti-infective material
• Antibacterial biomaterials
• Antibiotic coating device
• Antibiotic release
• Antimicrobial biomaterials
• Antimicrobial coating device
• Antimicrobial device
• Antimicrobial-Modified Vascular Catheters
• BAI
• Biomaterial dendritic cell interactions
• Coagulase negative staphylococci infection
• Colonization of tissue surrounding inserted medical devices
• Dendritic cell-biomaterial interactions
• Implant associated infection
• Infection of inserted or implanted medical devices
• Intracellular bacteria
• Medical device associated infection
• Peri-implant tissue colonization
• Peri-implantitis biofilm
• Preventive Strategies in VAP
• Propionibacterium acnes
• Quaternary ammonium Compounds
• Rifampin biofilm
• S. epidermidis biofilm interactions
• S. epidermidis/ S. aureus biofilm
• Silver containing biomaterials
• Staphylococcal virulence factors
• Staphylococcus aureus
• Staphylococcus aureus implant associated infection
• Staphylococcus aureus infection of implanted medical devices
• Staphylococcus aureus medical device associated infection
• Staphylococcus epidermidis
• Staphylococcus epidermidis implant associated infection
• Staphylococcus epidermidis infection of inserted medical devices
• Staphylococcus epidermidis medical device associated infection
• biofilm formation biomaterial
• biomaterial antimicrobials
• biomaterial associated infection
• biomaterial implanted biomaterials immunology
• foreign body response
• immune function implanted biomaterial
• immune response implanted
• indwelling bladder catheter
• indwelling bladder catheter infection
• race for the surface
• tissue colonisation in BAI
• tissue infection

• AO Research Institute Davos, Davos Platz, Switzerland

  T. Fintan Moriarty

• , Medical Microbiology, Academic Medical Center, Amsterdam, Netherlands

  Sebastian A.J. Zaat

• University Medical Center Groningen, Groningen, Netherlands

  Henk J. Busscher

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