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Myocardial Ischemia and Preconditioning

  • Book
  • © 2003

Overview

Editors:
  1. Naranjan S. Dhalla

    1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  2. Nobuakira Takeda

    1. Aoto Hospital, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

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  3. Manjeet Singh

    1. Dept. of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India

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  4. Anton Lukas

    1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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Part of the book series: Progress in Experimental Cardiology (PREC, volume 6)

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Table of contents (35 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Ischemia/Reperfusion Injury: Basic Mechanisms

    1. Front Matter

      Pages 1-1
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    2. PTCA acutely expands perfused myocardial mass and increases flow homogeneity

      • Gianmario Sambuceti, Mario Marzilli, Andrea Mari, Cecilia Marini, Mathis Schluter, Paolo Marzullo et al.
      Pages 3-12

    3. Angiogenic Therapy by Coronary Collateral Recruitment and Arteriogenesis

      • Masatoshi Fujita
      Pages 13-22

    4. Regulatory Role of ERK—Dependent Pathways in Activity of the Na+/H+ Exchanger in the Healthy and Ischemic Myocardium

      • Larry Fliegel, Morris Karmazyn, Andrea N. Moor
      Pages 23-33

    5. Sodium Overload and Mitochondrial Damage in Ischemic/Reperfused Heart

      • Satoshi Takeo, Takeshi Iwai, Kouichi Tanonaka
      Pages 35-60

    6. Antisense-Induced Underexpression of Manganese Superoxide Dismutase Extends Myocardial Ischemia-Reperfusion Injury

      • Shiro Hoshida, Nobushige Yamashita, Kinya Otsu, Masatsugu Hori
      Pages 61-70

    7. Phospholamban Phosphorylation during Ischemia and Reperfusion Injury: Mechanisms and Functional Implications

      • Alicia Mattiazzi, Cecilia Mundiña-Weilenmann, Leticia Vittone, Matilde Said, Paola Ferrero
      Pages 71-81

    8. Phospholipase C-Mediated Signaling in Ischemic Heart Disease

      • Paramjit S. Tappia, Girma Asemu, Naranjan S. Dhalla
      Pages 83-93

    9. Effects of Sequential Ischemia-reperfusion Cycles on Cyclic Nucleotide Phosphodiesterase Activity in Pig Heart

      • Thomas Podzuweit, Markus Schmook, Klaus Binz, Sylvia Thomas
      Pages 95-125

    10. Inducible Nitric Oxide Synthase in Cardiac Adaptation to Ischemia

      • Ján Slezák, Jan Styk, Olga Slezakova, Gerd Wallukat, Peter Karczewski, Wolfgang Schulze et al.
      Pages 127-138

    11. Long Term Follow-Up of Leukocyte Function during Myocardial Reperfusion Injury

      • Elizabeth Röth, Gábor Jancsó, Gyula Temes, János Lantos
      Pages 139-148

    12. Mechanisms of Cellular Alterations Due to Ischemia-Reperfusion Injury in the Heart

      • Rana M. Temsah, Thomas Netticadan, Naranjan S. Dhalla
      Pages 149-164

    13. Mechanisms for Ischemia/Reperfusion Injury: Application of 23Na Magnetic Resonance Spectroscopy

      • Kenichi Imahashi, Hideo Kusuoka
      Pages 165-177

  3. Mechanisms Underlying Ischemic Preconditioning-Induced Cardioprotection

    1. Front Matter

      Pages 179-179
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    2. Is Reduced Cell Swelling a Plausible End-Effector of Ischemic Preconditioning Protection?

      • Charles E. Ganote, Stephen C. Armstrong
      Pages 181-188

    3. Cardioprotection by Mitochondrial KATP Channel in Both Early and Late Preconditioning

      • Yigang Wang, Meifeng Xu, Mitsuhiro Kudo, Ahmar Ayub, Muhammad Ashraf
      Pages 189-204

    4. Role of Mitochondrial Membrane Potential in Cardiac Protection against Ischemia

      • Meifeng Xu, Yigang Wang, Ahmar Ayub, Muhammad Ashraf
      Pages 205-218

    5. Hypoxic Reperfusion after Brief Ischemia Potentiates Ischemic Preconditioning in Isolated Rat Hearts

      • Marie-Claire Toufektsian, Stéphane Tanguy, Sandrine Morel, Nada Benajiba, François Boucher, Joël de Leiris
      Pages 219-233

    6. Molecular Basis for the Cardioprotective Effect of Herbal Drugs in Ischemic Heart Disease: An Experimental Study

      • Suresh Kumar Gupta, Meenu Sharma, Ipseeta Mohanty, Dharamvir S. Arya
      Pages 235-248
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Keywords

About this book

Current evidence suggests that the ischemic preconditioning response is a multi-factorial process consisting of an initial early trigger, an intermediate mediator, and an end effector. Each of these steps in is now its own intense area of investigation. The need to render the heart ischemic for a brief period to invoke the preconditioning response is currently the major factor limiting clinical application of this powerful cardioprotective strategy. Recent research efforts have utilized brief exposures to pharmacological agents, in lieu of a brief preconditioning ischemia, to trigger/mimic the ischemic preconditioning-induced response. The World Heart Congress held in Winnipeg in July 2001 provided a forum for the presentation of new insights into the basic mechanisms of ischemia and reperfusion injury, as well as novel strategies to protect the heart from cell death, ventricular arrhythmias, and contractile dysfunction. Many pioneers in the fields of ischemia-reperfusion injury and preconditioning-induced protection presented there and the chapters in this book represent selected papers from these symposia.

Editors and Affiliations

  • Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla, Anton Lukas

  • Aoto Hospital, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Nobuakira Takeda

  • Dept. of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India

    Manjeet Singh

Bibliographic Information

  • Book Title: Myocardial Ischemia and Preconditioning

  • Editors: Naranjan S. Dhalla, Nobuakira Takeda, Manjeet Singh, Anton Lukas

  • Series Title: Progress in Experimental Cardiology

  • DOI: https://doi.org/10.1007/978-1-4615-0355-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-1-4020-7195-9Published: 31 December 2002

  • Softcover ISBN: 978-1-4613-5036-1Published: 01 November 2012

  • eBook ISBN: 978-1-4615-0355-2Published: 06 December 2012

  • Series ISSN: 1389-1774

  • Edition Number: 1

  • Number of Pages: XVII, 541

  • Topics: Cardiology

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