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Chemistry - Polymer Science | Light-Sensitive Polymeric Nanoparticles Based on Photo-Cleavable Chromophores

Light-Sensitive Polymeric Nanoparticles Based on Photo-Cleavable Chromophores

Series: Springer Theses

Klinger, Daniel

2013, XVII, 224 p. 108 illus., 21 illus. in color.

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  • Nominated as an outstanding Ph.D. thesis by the Max-Planck Institute for Polymer Research
  • Describes a versatile method for controlling the properties of light-responsive microgels and nanoparticles through molecular design of  the respective building blocks
  • Demonstrates the effective synergy between different disciplines and forms the basis for a number of publications in internationally renowned journals
The triggered release of functional compounds from such polymeric carriers as micelles, nanoparticles or nanogels is a rapidly developing and highly versatile concept which is expected to be one of the key approaches to future therapeutics. In his thesis, Daniel Klinger highlights the approach of stimuli-responsive microgels for such applications and discusses why especially light as a trigger has an outstanding position amongst the family of conventional stimuli. Based on these considerations, the author focuses on the design, synthesis and characterization of novel photo-sensitive microgels and nanoparticles as potential materials for the loading and light-triggered release/accessibility of functional compounds. Starting from the synthesis of photo-cleavable organic building blocks and their use in the preparation of polymeric nanoparticles, continuing to the examination of their loading and release profiles, and concluding with biological in vitro studies of the final materials, Daniel Klinger’s work is an excellent example of the multidisciplinary research needed for the successful development of new materials in this field and has led to a number of further publications in internationally respected journals.

Content Level » Research

Keywords » Hydrogel Nanoparticles - Light-Sensitive Nanoparticles - Light-Triggered Release - Miniemulsion Polymerization - Photo-Cleavable Crosslinkers - Photochemical Nanotechnology - Polymer Chemistry - Stimuli-Responsive Microgels

Related subjects » Condensed Matter Physics - Nanotechnology - Polymer Science

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