Overview
- Presents the design and development of pyruvate dehydrogenase complex (PDHc) inhibitors as effective novel herbicides
- Introduces the systematical approach to develop novel alkylphosphonates with desirable biological activities
- Covers the results of research and development of environmentally friendly alkylphosphonate herbicides
- Includes supplementary material: sn.pub/extras
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Table of contents (9 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This book presents essential research on a class of environmentally friendly alkylphosphonate herbicides. This class of herbicides acted as a competitive inhibitor of the pyruvate dehydrogenase complex (PDHc) to control weeds. The bioreasoning and systematic approach, from basic research to field tests of candidate compounds, are introduced. The basic research covers the molecular design, chemical synthesis, biological activities evaluation, structure-activity relationship analysis and structural optimization. Subsequently, the book reviews the biochemistry of PDHc inhibitors, the selectivity between mammals and plants, and the mechanism of herbicidal activity of novel alkylphosphonates as selective PDHc inhibitors. Field trials for selected alkylphosphonate candidates as herbicides are also included. This book provides a sound basis for the rational design and development of novel herbicides as effective PDHc inhibitors with good enzyme-selective inhibition of plant PDHc between mammals and plants. These studies take full advantages of the low toxicity and low residual impact of selective PHDc inhibitors to design an effective and environmentally friendly herbicide. This book is based on twenty years of research on alkylphosphonates and phosphorus-containing PDHc inhibitors, and demonstrates how to develop these PDHc inhibitors as an effective and “green” herbicide candidate.
Hong-Wu He, PhD, is a Professor at the Key Laboratory of Pesticide & Chemical Biology, Ministry of Education of China, and Director of the Institute of Pesticide Chemistry, College of Chemistry, Central China Normal University, China.
Hao Peng, PhD, and Xiao-Song Tan are both Associate Professors at the Key Laboratory of Pesticide & Chemical Biology, Ministry of Education of China, College of Chemistry, Central China Normal University, China.
Authors and Affiliations
Bibliographic Information
Book Title: Environmentally Friendly Alkylphosphonate Herbicides
Authors: Hong-Wu He, Hao Peng, Xiao-Song Tan
DOI: https://doi.org/10.1007/978-3-662-44431-3
Publisher: Springer Berlin, Heidelberg
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Chemical Industry Press, Beijing and Springer-Verlag Berlin Heidelberg 2014
Hardcover ISBN: 978-3-662-44430-6Published: 18 November 2014
Softcover ISBN: 978-3-662-51284-5Published: 10 September 2016
eBook ISBN: 978-3-662-44431-3Published: 04 November 2014
Edition Number: 1
Number of Pages: XXIV, 455
Number of Illustrations: 441 b/w illustrations
Additional Information: Jointly published with Chemical Industry Press, Beijing, China
Topics: Organic Chemistry, Plant Biochemistry, Environmental Chemistry, Agriculture