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Chemistry - Organic Chemistry | Environmentally Friendly Alkylphosphonate Herbicides

Environmentally Friendly Alkylphosphonate Herbicides

He, Hong-Wu, Peng, Hao, Tan, Xiao-Song

Jointly published with Chemical Industry Press, Beijing, China

2014, XXIV, 455 p. 441 illus.

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  • Presents the design and development of pyruvate dehydrogenase complex (PDHc) inhibitors as effective novel herbicides
  • Introduces the systematical approach to develop novel alkylphosphonates with desirable biological activities
  • Covers the results of research and development of environmentally friendly alkylphosphonate herbicides

This book presents essential research on a class of environmentally friendly alkylphosphonate herbicides. This class of herbicides acted as a competitive inhibitor of the pyruvate dehydrogenase complex (PDHc) to control weeds. The bioreasoning and systematic approach, from basic research to field tests of candidate compounds, are introduced. The basic research covers the molecular design, chemical synthesis, biological activities evaluation, structure-activity relationship analysis and structural optimization. Subsequently, the book reviews the biochemistry of PDHc inhibitors, the selectivity between mammals and plants, and the mechanism of herbicidal activity of novel alkylphosphonates as selective PDHc inhibitors. Field trials for selected alkylphosphonate candidates as herbicides are also included. This book provides a sound basis for the rational design and development of novel herbicides as effective PDHc inhibitors with good enzyme-selective inhibition of plant PDHc between mammals and plants. These studies take full advantages of the low toxicity and low residual impact of selective PHDc inhibitors to design an effective and environmentally friendly herbicide. This book is based on twenty years of research on alkylphosphonates and phosphorus-containing PDHc inhibitors, and demonstrates how to develop these PDHc inhibitors as an effective and “green” herbicide candidate.  

Hong-Wu He, PhD, is a Professor at the Key Laboratory of Pesticide & Chemical Biology, Ministry of Education of China, and Director of the Institute of Pesticide Chemistry, College of Chemistry, Central China Normal University, China.
Hao Peng, PhD, and Xiao-Song Tan are both Associate Professors at the Key Laboratory of Pesticide & Chemical Biology, Ministry of Education of China, College of Chemistry, Central China Normal University, China.

Content Level » Research

Keywords » Alkylphosphinates - Alkylphosphonates - Biorational design - Caged Bicyclic Phosphates - Clacyfos - Cyclic Phosphonates - Environment-friendly Herbicides - Herbicidal activity - PDHc inhibitor - Pyruvate dehydrogenase complex

Related subjects » Agriculture - Biochemistry & Biophysics - Environmental Chemistry - Organic Chemistry

Table of contents / Preface / Sample pages 

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Distribution rights for China: Chemical Industry Press, Beijing, China

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