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Provides an overview of the present state and future perspectives of drug discovery at protein-protein interfaces
Gives details of both computational and experimental tools used in the field
Gives positive examples of drug-like molecules effective in interacting at protein-protein interfaces
"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.
Content Level »Research
Keywords »Dissociative inhibition model - Drug discovery - Inhibitors design - Inhibitors of protein-protein interactions - Interface directed inhibitors - Ligand binding sites at protein interfaces - Protein-protein interfaces as drug targets - Quaternary structure inhibitors