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Heterocyclic chemistry is the biggest branch of chemistry covering two-third of the chemical literature
Covers hot topics of frontier research summarized by reputed scientists in the field
Our review series is topic related
Online version available on SpringerLink.com
As part of the series Topics in Heterocyclic Chemistry,this volume titled Bio- tive Heterocycles II presents comprehensive and up-to-date reviews on selected topics regarding synthetic as well as naturally occurring bioactive heterocycles. The ?rst chapter, “High Pressure Synthesis of Heterocycles Related to Bio- tive Molecules” by Kiyoshi Matsumoto, presents a unique high-pressure s- thetic methodology in heterocyclic chemistry. Basic principles and fruitful examples for pericyclic reactions, such as Diels-Alder reactions, 1,3-dipolar reactions, and also for ionic reactions, such as S and addition reactions, are N discussed. The review will be of considerable interest to heterocyclic chemists and synthetic chemists. The second chapter, “Ring Transformation of Nitropyrimidinone Leading to Versatile Azaheterocyclic Compounds” by Nagatoshi Nishiwaki and Masahiro Ariga, presents a very critical review on novel ring transformations of di- tropyridones and nitropyrimidinones based on the work of his group. - dressed in this review is the synthesis of functionalized molecules, such as nitroanilines, nitropyridines, and nitrophenols, by the ring transformation of dinitropyridones as the nitromalonaldehyde equivalent. Ring transformations of nitropyrimidinones with dinucleophiles to 4-pyridones, pyrimidines and 4-aminopyridines, and to polyfunctinal pyridones with 1,3-dicarbonyl c- pounds, etc., are also discussed. This review may attract the interest of synthetic chemists as well as heterocyclic chemists in the life science ?elds. The third chapter, “Synthesis of Thalidomide” by Norio Shibata, Takeshi Yamamoto and Takeshi Toru, describes a modern synthetic aspect of thali- mide.
K. Matsumoto: High Pressure Synthesis of Heterocycles Related to Bioactive Molecules.- N. Nishiwaki, M. Ariga: Ring Transformation of Nitropyrimidinone Leading to Versatile Azaheterocyclic Compounds.- N. Shibata, T. Yamamoto, T. Toru: Synthesis of Thalidomide.- H. Nagase, H. Fujii: Rational Drug Design of d Opioid Receptor Agonist TAN-67 from d Opioid Receptor Antagonist NTI.- S. Murata, H. Ichinose, F. Urano: Tetrahydrobiopterin and Related Biologically Important Pterins.- M. Yamashita: Preparation, Structure and Biological Property of Phosphorus Heterocycles with a C-P Ring System.- K. Michalak, O. Wesolowska, N. Motohashi, A.B. Hendrich: The Role of the Membrane Actions of Phenothiazines and Flavonoids as Functional Modulators