Microdroplet Technology

1. Front Matter

   Pages i-x

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2. Physics of Multiphase Microflows and Microdroplets

   • Yonghao Zhang, Haihu Liu

   Pages 1-21

3. Microfluidic Droplet Manipulations and Their Applications

   • Melinda G. Simon, Abraham P. Lee

   Pages 23-50

4. Active Control of Droplet Formation Process in Microfluidics

   • Nam-Trung Nguyen, Say-Hwa Tan

   Pages 51-75

5. Recent Advances in Electrowetting Microdroplet Technologies

   • Robert W. Barber, David R. Emerson

   Pages 77-116

6. Automated Droplet Microfluidic Chips for Biochemical Assays

   • Tomasz S. Kaminski, Krzysztof Churski, Piotr Garstecki

   Pages 117-136

7. The Dropletisation of Bio-Reactions

   • Ehsan Karimiani, Amelia Markey, Philip Day

   Pages 137-147

8. Droplet-Based Microfluidics as a Biomimetic Principle: From PCR-Based Virus Diagnostics to a General Concept for Handling of Biomolecular Information

   • J. Michael Köhler

   Pages 149-178

9. Droplet Microreactors for Materials Synthesis

   • Nick J. Carroll, Suk Tai Chang, Dimiter N. Petsev, Orlin D. Velev

   Pages 179-209

10. Single-Cell Analysis in Microdroplets

    • Michele Zagnoni, Jonathan M. Cooper

    Pages 211-228

11. Trends and Perspectives

    • Pavel NeuZ̆il, Ying Xu, Andreas Manz

    Pages 229-239

12. Back Matter

    Pages 241-243

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Microdroplet technology has recently emerged to provide new and diverse applications via microfluidic functionality, especially in various areas of biology and chemistry. This book, then, gives an overview of the principle components and wide-ranging applications for state-of-the-art of droplet-based microfluidics. Chapter authors are internationally-leading researchers from chemistry, biology, physics and engineering that present various key aspects of micrdroplet technology -- fundamental flow physics, methodology and components for flow control, applications in biology and chemistry, and a discussion of future perspectives. This book acts as a reference for academics, post-graduate students, and researcher wishing to deepen their understand of microfluidics and introduce optimal design and operation of new droplet-based microfluidic devices for more comprehensive analyte assessments.

• DNA diagnostics
• Flow control
• digital microfluidics
• electrowetting
• microdroplet
• microfluidic
• micropumps
• microvalves
• multiphase microflows
• single-cell

• , Manchester Instit. of Biotechnology, University of Manchester, Manchester, United Kingdom

  Philip Day

• KIST Europe, Saarbrucken, Germany

  Andreas Manz

• Dept. Mechan. & Aerospace Eng., University of Strathclyde, Glasgow, United Kingdom

  Yonghao Zhang

Yonghao Zhang, Senior Lecturer in Mechanical Engineering, Strathclyde University, Glasgow, Scotland. During his career, he worked at the Department of Engineering, University of Aberdeen, Scotland; and the Daresbury Laboratory, Warrington, England.

Philip Day, Reader in Quantitative Analytical Genomics, CIGMR, Faculty of Medicine, and Principal Investigator at the Manchester Interdisciplinary Biocentre, The University of Manchester, England. During his career, he worked at the Birmingham Children's Hospital, England; the Wellcome Trust Centre for Complex Diseases, Oxford, England; Department of Biochemistry, Oxford University, England;founded the Functional Genomics Unit, Children's University Hospital, Zurich, Switzerland; and at ISAS, Institute for Analytical Sciences, Dortmund, Germany.

Andreas Manz, Professor in Micro Systems for Life Sciences, Department of Physics and Mechatronics, The Saarland University, and Head of Research, KIST Europe, Saarbrucken, Germany. During his career, he worked at the Chemistry Department, ETH Zurich, Switzerland; at Hitachi Corp., Tokyo, Japan; at Corporate Research, Ciba-Geigy Corp, Basel, Switzerland; at the Chemistry Department, Imperial College London, England; at Caliper Corp., Palo Alto, USA; at the Department of Biochemical and Chemical Engineering, Technical University Dortmund, Germany; at the ISAS, Institute for Analytical Sciences, Dortmund, Germany; and at FRIAS, Freiburg Institute for Advanced Studies, University of Freiburg, Germany.

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