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Mathematical Modeling and Scale-up of Liquid Chromatography

  • Book
  • © 1995

Overview

Authors:
  1. Tingyue Gu

    1. Dept. of Chemical Engineering, Stocker Center, Ohio University, Athens, USA

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Introduction

    • Tingyue Gu
    Pages 1-3

  3. Literature Review

    • Tingyue Gu
    Pages 4-8

  4. A General Multicomponent Rate Model for Column Liquid Chromatography

    • Tingyue Gu
    Pages 9-31

  5. Mass Transfer Effects

    • Tingyue Gu
    Pages 32-38

  6. Interference Effects in Multicomponent Chromatography

    • Tingyue Gu
    Pages 39-51

  7. System Peaks in Multicomponent Elution

    • Tingyue Gu
    Pages 52-70

  8. Multicomponent Adsorption with Uneven Saturation Capacities

    • Tingyue Gu
    Pages 71-80

  9. Modeling of Affinity Chromatography

    • Tingyue Gu
    Pages 81-94

  10. Modeling of Multicomponent Gradient Elution

    • Tingyue Gu
    Pages 95-101

  11. Multicomponent Radial Flow Chromatography

    • Tingyue Gu
    Pages 102-110

  12. Scale-Up of Liquid Chromatography using General Rate Models

    • Tingyue Gu
    Pages 111-120

  13. References

    • Tingyue Gu
    Pages 121-123

  14. Back Matter

    Pages 125-129
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Keywords

About this book

Liquid chromatography has proved to be one of the most important tools for separations. Rapid development in biotechnology has increased the demand for chromatography in analytical, preparative and large scale applications. The understanding of the dynamics of chromatography is imperative for the scale-up. This book is a systematic treatment of the general rate models for various forms of liquid chromatography including adsorption, size exclusion, affinity, reversed phase, hydrophobic interaction, and radial flow chromatography. Thermodynamic and mass transfer effects in liquid chromatography are discussed. Applications of computer programs for the rate models are described and the procedures for the scale-up of preparative- and large-scale liquid chromatography using the general rate models are given.

Authors and Affiliations

  • Dept. of Chemical Engineering, Stocker Center, Ohio University, Athens, USA

    Tingyue Gu

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