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PET Chemistry

The Driving Force in Molecular Imaging

  • Conference proceedings
  • © 2007

Overview

Editors:
  1. P. A. Schubiger

    1. Animal Imaging Center — PET, Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Hönggerberg D-CHAB, Zürich, Switzerland

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  2. L. Lehmann

    1. Corporate Research, Schering AG, Berlin, Germany

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  3. M. Friebe

    1. Corporate Research, Schering AG, Berlin, Germany

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  • State-of-the-art information on the different applications of PET isotopes
  • Includes supplementary material: sn.pub/extras

Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 62)

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Table of contents (13 papers)

  1. Front Matter

    Pages I-XII
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  2. Molecular Imaging with PET — Open Questions?

    • P. A. Schubiger
    Pages 1-13

  3. Fluorine-18 Labeling Methods: Features and Possibilities of Basic Reactions

    • H. H. Coenen
    Pages 15-50

  4. Fluorine-18 Labeling of Small Molecules: The Use of 18F-Labeled Aryl Fluorides Derived from No-Carrier-Added [18F]Fluoride as Labeling Precursors

    • F. Wuest
    Pages 51-78

  5. Fluorine-18 Labeling of Peptides and Proteins

    • H. J. Wester, M. Schottelius
    Pages 79-111

  6. [18F]Fluoropyridines: From Conventional Radiotracers to the Labeling of Macromolecules Such as Proteins and Oligonucleotides

    • F. Dollé
    Pages 113-157

  7. Production of Non-standard PET Radionuclides and the Application of Radiopharmaceuticals Labeled with these Nuclides

    • M. J. Welch, R. Laforest, J. S. Lewis
    Pages 159-181

  8. Carbon-11 Labeling Chemistry Based upon [11C]Methyl Iodide

    • F. Wuest, M. Berndt, T. Kniess
    Pages 183-213

  9. 68Ga-PET Radiopharmacy: A Generator-Based Alternative to 18F-Radiopharmacy

    • H. R. Maecke, J. P. André
    Pages 215-242

  10. Microwaving in F-18 Chemistry: Quirks and Tweaks

    • S. Stone-Elander, N. Elander, J. -O. Thorell, A. Fredriksson
    Pages 243-269

  11. Micro-reactors for PET Tracer Labeling

    • S. Y. Lu, V. W. Pike
    Pages 271-287

  12. Synthesis Modules and Automation in F-18 Labeling

    • R. Krasikova
    Pages 289-316

  13. Pharmacological Prerequisites for PET Ligands and Practical Issues in Preclinical PET Research

    • S. M. Ametamey, M. Honer
    Pages 317-327

  14. Positron Emission Tomography Imaging as a Key Enabling Technology in Drug Development

    • T. J. McCarthy
    Pages 329-339

  15. Back Matter

    Pages 341-345
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Keywords

About this book

Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for speci?c e- point monitoring in modern drug development. PET (positron emitting tomography), a nuclear medical imaging modality, is ideally suited to produce three-dimensional images of various targets or processes. The rapidly increasing demand for highly selective probes for MI strongly pushes the development of new PET tracers and PET chemistry. ‘PET chemistry’ can be de?ned as the study of positron-emitting compounds regarding their synthesis, structure, composition, reactivity, nuclear properties and processes and their properties in natural and - natural environments. In practice PET chemistry is strongly in?uenced by the unique properties of the radioisotopes used (e. g. , half-life, che- cal reactivity, etc. ) and integrates scienti?c aspects of nuclear-, organic-, inorganic- and biochemistry.

Editors and Affiliations

  • Animal Imaging Center — PET, Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Hönggerberg D-CHAB, Zürich, Switzerland

    P. A. Schubiger

  • Corporate Research, Schering AG, Berlin, Germany

    L. Lehmann, M. Friebe

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