Small Molecule Therapeutics for Schizophrenia

1. Front Matter

   Pages i-vii

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2. Antipsychotics and the Dopamine–Serotonin Connection

   • Bart A. Ellenbroek, Andrea M. Cesura

   Pages 1-49

3. GlyT-1 Inhibitors: From Hits to Clinical Candidates

   • Roderick A. Porter, Lee A. Dawson

   Pages 51-99

4. Metabotropic Glutamate Receptor 2 Activators

   • José M. Cid, Andrés A. Trabanco, Hilde Lavreysen

   Pages 101-142

5. Activation of the mGlu5 Receptor for the Treatment of Schizophrenia and Cognitive-Deficit-Associated Disorders

   • Theresa Williams, Marlene A. Jacobson, Mikhail Kalinichev, Jean-Philippe Rocher

   Pages 143-182

6. Muscarinic Acetylcholine Receptor Activators

   • Takaaki Sumiyoshi, Takeshi Enomoto

   Pages 183-211

7. Nicotinic Acetylcholine Receptor Modulators

   • Anatoly Mazurov, Daniel Yohannes

   Pages 213-253

8. The Use of PDE10A and PDE9 Inhibitors for Treating Schizophrenia

   • Jamison B. Tuttle, Bethany L. Kormos

   Pages 255-316

9. Back Matter

   Pages 317-323

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The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.

• 5HT Receptor Ligands
• DA Receptor Ligands
• GLYT1 Inhibitors
• PDE10/PDE9 Inhibitors
• mACh Activators
• mGlu2 Activators
• mGlu5 Positive Allosteric Modulators
• nACh Activators
• psychopharmacology

From the book reviews:

“The target audience … is primarily researchers in psychopharmacology involved in drug development. … Each chapter concludes with citations of the pertinent scientific literature. This book covering small molecular therapeutics for schizophrenia would be a useful review for researchers studying this area.” (Michael Joel Schrift, Doody’s Book Reviews, March, 2015)

• Reigner, France

  Sylvain Celanire

• Addex Therapeutics, Geneva, Switzerland

  Sonia Poli

Policies and ethics