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  • © 2008

Pharmacogenomics in Drug Discovery and Development

Editors:

  • Examines both fundamental concepts and advanced technologies in pharmacogenomics
  • Uses cutting-edge technologies to pursue systems-based pharmacogenomics, including bioinformatics, microarray, and association studies
  • Methodical, state-of-the-art contributions covering topics from individual molecules, gene-drug interactions, to systemic diseases presented by leading experts
  • Explores extensive applications of pharmacogenomics in drug development for diseases including psychiatric disorders, cardiovascular diseases, cancer, Alzheimer's disease, rheumatoid arthritis, asthma, and infectious diseases
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 448)

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Table of contents (17 protocols)

  1. Front Matter

    Pages i-xiii
  2. Pharmacogenetics of Membrane Transporters

    • Tristan M. Sissung, Erin R. Gardner, Rui Gao, William D. Figg
    Pages 41-62
  3. Pharmacogenomics of G Protein-Coupled Receptor

    • Miles D. Thompson, David E. C. Cole, Pedro A. Jose
    Pages 77-107
  4. G Protein-Coupled Receptors Disrupted in Human Genetic Disease

    • Miles D. Thompson, Maire E. Percy, W. McIntyre Burnham, David E. C. Cole
    Pages 109-137
  5. G Protein-Coupled Receptor Pharmacogenetics

    • Miles D. Thompson, Katherine A. Siminovitch, David E. C. Cole
    Pages 139-185
  6. Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders

    • Hamid Mostafavi Abdolmaleky, Cassandra L. Smith, Jin-Rong Zhou, Sam Thiagalingam
    Pages 187-212
  7. Pharmacogenomics in Alzheimer's Disease

    • Ramón Cacabelos
    Pages 213-357
  8. Pharmacogenetics of Asthma

    • Gregory A. Hawkins, Stephen P. Peters
    Pages 359-378
  9. Pharmacogenomics in Gastrointestinal Disorders

    • Michael Camilleri, Yuri A. Saito
    Pages 395-412
  10. Pharmacogenomics in Rheumatoid Arthritis

    • Prabha Ranganathan
    Pages 413-435
  11. Cancer Pharmacogenetics

    • Sharon Marsh
    Pages 437-446
  12. Back Matter

    Pages 481-487

About this book

Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases.

Comprehensive and up-to-date, Pharmacogenomics in Drug Discovery and Development is an ideal volume for scientists striving to transform disease treatment into disease prevention.

Reviews

From the reviews:

"This volume in the Methods in Molecular Biology series covers pharmacogenomics in drug discovery. … The book is intended for scientists in academic, industrial, and health care settings who are striving to transform disease treatment into disease prevention. … The advanced technologies are presented in a very detail manner, even including step-by-step protocols. … By covering topics from individual molecules to systemic diseases … this book provides an overview of current knowledge on the use of pharmacogenomics in therapeutics of disease." (Xiaobo Zhong, Doody’s Review Service, July, 2008)

Editors and Affiliations

  • PharmTao, Santa Clara, USA

    Qing Yan

Bibliographic Information

  • Book Title: Pharmacogenomics in Drug Discovery and Development

  • Editors: Qing Yan

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-59745-205-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2008

  • Hardcover ISBN: 978-1-58829-887-4Published: 19 March 2008

  • Softcover ISBN: 978-1-61737-825-6Published: 19 November 2010

  • eBook ISBN: 978-1-59745-205-2Published: 22 March 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIII, 487

  • Topics: Medicinal Chemistry, Pharmacology/Toxicology, Human Genetics, Cell Biology, Bioinformatics

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access