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  • © 2014

Upscaling of Bio-Nano-Processes

Selective Bioseparation by Magnetic Particles

  • Presents solutions for large scale bioprocessing of nanoparticles
  • Suggests a new application for magnetic particles for upscaling of protein separation
  • Addresses toxicological aspects related to food, pharmaceutical and feed industry
  • Includes supplementary material: sn.pub/extras

Part of the book series: Lecture Notes in Bioengineering (LNBE)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xvii
  2. Introduction

    • Hermann Nirschl
    Pages 1-12
  3. Particle Synthesis and Functionalization

    1. Front Matter

      Pages 13-13
    2. Magnetic Microgels: Synthesis and Characterization

      • Rodica Turcu, Izabell Craciunescu, Alexandrina Nan
      Pages 57-76
    3. Vesicles and Composite Particles by Rotating Membrane Pore Extrusion

      • Elisabeth Rondeau, Sebastian Holzapfel, Helen Engel, Erich J. Windhab
      Pages 77-96
    4. Synthesis of Functionalized Magnetic Beads Using Spray Drying

      • Valéry Tchanque Kemtchou, Maria Schäfer, Urs Alexander Peuker
      Pages 97-116
  4. Magnetic Separation Devices

    1. Front Matter

      Pages 129-129
    2. Magnetically Enhanced Centrifugation for Industrial Use

      • Johannes Lindner, Karsten Keller, Gunnar Grim, Johannes Feller, Christian Fiil Nielsen, Niels Dalgaard et al.
      Pages 131-146
    3. Continuous Magnetic Extraction for Protein Purification

      • Anja Paulus, Matthias Franzreb
      Pages 175-186
  5. Process Examples

    1. Front Matter

      Pages 187-187
    2. In Situ Magnetic Separation on Pilot Scale: A Tool for Process Optimization

      • Alexander Scholz, Martin Cerff, Clemens Posten
      Pages 189-211
    3. An Industrial Approach to High Gradient Magnetic Fishing in the Food Industry

      • Christian Fiil Nielsen, Karsten Keller, Susanne Rasmussen, Niels Dalgaard, Timothy John Hobley, Wickie Sondergaard et al.
      Pages 213-233
  6. Conclusion

    1. Front Matter

      Pages 235-235
    2. Conclusion

      • Johannes Lindner, Karsten Keller, Hermann Nirschl
      Pages 237-241
  7. Back Matter

    Pages 243-245

About this book

Despite ongoing progress in nano- and biomaterial sciences, large scale bioprocessing of nanoparticles remains a great challenge, especially because of the difficulties in removing unwanted elements during processing in food, pharmaceutical and feed industry at production level. This book presents magnetic nanoparticles and a novel technology for the upscaling of protein separation. The results come from the EU Project "MagPro2Life", which was conducted in cooperation of several european institutions and companies.

Editors and Affiliations

  • Institute of Mechanical Process Engineering and Mechanics, Karlsruhe Institute of Technology, Karlsruhe, Germany

    Hermann Nirschl

  • DuPont, Wilmington, USA

    Karsten Keller

About the editors

Prof. Dr.-Ing. Hermann Nirschl is head of chair of process machinery at the institute of mechanical process engineering and mechanics at the Karlsruhe Institute of Technology, focusing on process machinery in solid liquid separation, blending, milling, nanoscaled particle structures and numerical simulation.

Dr. Karsten Keller is an Engineering Fellow of the Discovery Research group at Solae LLC (JV of DuPont) and has over 20 years of process engineering experience. He is developing novel processes for protein and new product opportunities from the lab-scale to commercial production and is the author of over 70 publications on subjects of separation, modeling, particle technology, biotechnology and nanotechnology. He is the inventor of 8 patents worldwide.

Bibliographic Information

  • Book Title: Upscaling of Bio-Nano-Processes

  • Book Subtitle: Selective Bioseparation by Magnetic Particles

  • Editors: Hermann Nirschl, Karsten Keller

  • Series Title: Lecture Notes in Bioengineering

  • DOI: https://doi.org/10.1007/978-3-662-43899-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Engineering, Engineering (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2014

  • Hardcover ISBN: 978-3-662-43898-5Published: 15 August 2014

  • Softcover ISBN: 978-3-662-50983-8Published: 10 September 2016

  • eBook ISBN: 978-3-662-43899-2Published: 02 August 2014

  • Series ISSN: 2195-271X

  • Series E-ISSN: 2195-2728

  • Edition Number: 1

  • Number of Pages: XVII, 245

  • Number of Illustrations: 112 b/w illustrations, 29 illustrations in colour

  • Topics: Biotechnology, Biomaterials, Food Science

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access