Logo - springer
Slogan - springer

Chemistry - Analytical Chemistry | Structural and Functional Characterization of the Immunoproteasome

Structural and Functional Characterization of the Immunoproteasome

Series: Springer Theses

Huber, Eva Maria

2013, XIX, 82 p. 33 illus., 29 illus. in color.

Available Formats:

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.


(net) price for USA

ISBN 978-3-319-01556-9

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase

learn more about Springer eBooks

add to marked items


Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.


(net) price for USA

ISBN 978-3-319-01555-2

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days

add to marked items

  • Nominated as an outstanding Ph.D. thesis by the Technische Universität München, Germany
  • Detailed analysis of the X-ray structures of the murine immune- and constitutive proteasome
  • Yeast mutagenesis study to explore the differences between the constitutive proteasome, the immunoproteasome and the thymoproteasome
  • Inhibition studies on the immunoproteasome-selective compound ONX 0914

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

Content Level » Research

Keywords » Antigen Generation - Drugs for Cancers and Autoimmune Diseases - Immunoproteasome X-ray Structure - Proteasome Inhibition - Protein Crystallography - Proteolytic Degradation - Structure-based Drug Design - Ubiquitin-proteasome System

Related subjects » Analytical Chemistry - Chemistry

Table of contents / Sample pages 

Popular Content within this publication 



Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Analytical Chemistry.