Characterization of Protein Therapeutics using Mass Spectrometry
Chen, Guodong (Ed.)
2013, X, 404 p. 148 illus., 38 illus. in color.
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First book to focus on characterization by mass spectrometry of protein drugs
Edited by a well-known expert with strong ties to pharmaceutical industry and analytical chemistry
Internationally recognized contributors who are top experts in the field
Protein therapeutics’ high efficacy, safety, and ability to treat life-threatening diseases such as cancer, inflammation and genetic disorders have revolutionized modern medicine. In 2012, 200 companies competed in this $90 billion year industry.
In Characterization of Protein Therapeutics using Mass Spectrometry,expert contributors from academia and industry highlight current approaches and future trends. The book discusses mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies and quantitative approaches. The book also covers various studies involving characterization of process related protein drug impurities/degradants, metabolites, PTMs and higher order structures of protein therapeutics.
General practitioners in pharmaceutical research, specialists in analytical sciences, and graduate students studying mass spectrometry and pharmaceutical sciences will find this book useful because of the step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.
Content Level »Professional/practitioner
Keywords »Biologics - Drug Discovery - Genetics - LC/MS - MS - MS/MS - Mass Spectrometry - Peptides - Protein - Protein Characterization - Protein therapeutics - Protein therapy - Proteomics - large molecule - small molecule
1 Introduction to Protein Mass Spectrometry 2 Quantitative Analysis of Therapeutic and Endogenous Peptides Using LC/MS/MS Methods 3 The Development and Implementation of LC/MS-based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug 4 Post-Translationally Modified Proteins: Glycosylation and Disulfide Bond Formation 5 Mass Spectrometric Characterization in Protein Therapeutics Discovery 6 Molecular Variants Characterization in Protein Therapeutics Development 7 Mass Spectrometry of Antibody-Drug Conjugates in Plasma and Tissue in Drug Development 8 Hydrogen / Deuterium Exchange Mass Spectrometry for Protein Higher Order Structure Characterization 9 Fast Photochemical Oxidation of Proteins for Structural Characterization 10 Applications of Ion Mobility Mass Spectrometry for Characterization of Protein Therapeutics