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Th 17 Cells: Role in Inflammation and Autoimmune Disease

  • Book
  • © 2009

Overview

Editors:
  1. Valérie Quesniaux

    1. Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, Orléans, France

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  2. Bernhard Ryffel

    1. Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, Orléans, France

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    You can also search for this editor in PubMed   Google Scholar

  3. Franco Padova

    1. Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, Basel, Switzerland

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  • A topical volume describing in detail the Th17 cell population
  • Several new therapeutic targets are discussed in this context
  • International authorship
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xii
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  2. Introduction

    1. Introduction

      • Franco Di Padova, Bernhard Ryffel, Valérie Quesniaux
      Pages 1-9

  3. Discovery and IL-17 family

    1. Front Matter

      Pages 11-11
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    2. IL-22 and IL-17: Common and different properties

      • Robert Sabat, Katrin Witte, Kerstin Wolk
      Pages 13-38

    3. Other sources of IL-17: Invariant natural killer T cells

      • Marie-Laure Miche, Maria C. Leite-de-Moraes
      Pages 39-48

    4. Contributions of IL-22 to Th17 responses: Repairing and protecting peripheral tissues

      • Jean-Christophe Renauld, Laure Dumoutier
      Pages 49-60

    5. Retinoic acid in mucosal immune-regulation

      • Daniel Mucida, Hilde Cheroutre
      Pages 61-68

    6. IL-25, another promoter of allergy

      • Pornpimon Angkasekwinai, Chen Dong
      Pages 69-80

  4. Experimental models of disease

    1. Front Matter

      Pages 81-81
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    2. Critical role of IL-17 in experimental arthritis

      • Marije I. Koenders, Wim B. van den Berg
      Pages 83-94

    3. Dual role of IL-17 in allergic asthma

      • Bruno Schnyder, Silvia Schnyder-Candrian
      Pages 95-104

    4. Contribution of IL-17 to the pulmonary inflammatory response

      • Isabelle Couillin, Pamela Gasse, Francois Huaux, Silvia Schnyder-Candrian, Bruno Schnyder, François Erard et al.
      Pages 105-113

    5. The role of IL-17 in experimental autoimmune myocarditis

      • Alan Valaperti, Urs Eriksson
      Pages 115-126

    6. Th17 cells in organ transplantation

      • Ye Chen, Kathryn J. Wood
      Pages 127-132

  5. Role of IL-23/IL-17 in infection and tumor control

    1. Front Matter

      Pages 133-133
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    2. Is IL-17 required to control tuberculosis?

      • Andrea M. Cooper
      Pages 135-147

    3. IL-17 and mucosal host defense

      • Shabaana A. Khader, Jay K. Kolls
      Pages 149-159

    4. IL-23 orchestrates the switch from tumor immune surveillance to tumor-promoting inflammation

      • Martin Oft
      Pages 161-172

  6. IL-17 in clinical autoimmune disease

    1. Front Matter

      Pages 173-173
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    2. IL-17 and Th17 cells in rheumatoid arthritis

      • Pierre Miossec
      Pages 175-184
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Keywords

About this book

The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member’s expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion – pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on the potential role of Th17 in inflammatory diseases. Experimental studies confirmed that IL-17A is induced and is critical for the development of allergic lung inflammation, arthritis, bacterial sepsis, experimental allergic encephalomyelitis and myocarditis, as well as other inflammatory con- tions including organ transplantation. The role of IL-17F and IL-22 is still poorly defined and is only slowly emerging.

Reviews

From the reviews:

“This very interesting volume contains 18 reviews grouped in five chapters and presents the accumulated knowledge related to the IL-17 cytokines, a novel family of cytokines that defines a new effector T cell, the Th17 cell, and extends the Th1-Th2 paradigm. … This multi-authors volume is an exciting and rewarding reading for scientists and medical doctors exploring novel mechanisms of inflammation and therapy.” (Mihaela Trif, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)

Editors and Affiliations

  • Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, Orléans, France

    Valérie Quesniaux, Bernhard Ryffel

  • Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, Basel, Switzerland

    Franco Padova

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