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Cognitive function involves the participation of many different neurotransmitter systems in a variety of brain areas. The centerpiece of investigation regarding cognitive function has classically been the cholinergic system, but it has become increasingly clear that other transmitter systems interact with cholinergic systems to provide the neural basis for cognitive function.
This book brings together cutting edge research to determine how the transmitter interactions form the mechanistic bases for attention, learning and memory. This research on transmitter interactions not only provides a more accurate, though complex, picture of how the brain works to provide cognitive function, it also provides important new levels of understanding about the mechanisms of cognitive dysfunction and novel avenues for therapeutic treatment. The researchers who contributed to this volume both reviewed the latest findings but also point to the directions of advancement of the field of neurotransmitter interactions and cognitive function.
The rationale for studying transmitter interactions to understand the neural bases of cognitive function.- Neurotransmitters and cognition.- Interactions between CRF and acetylcholine in the modulation of cognitive behaviour.- Forebrain dopaminergic-cholinergic interactions, attentional effort, psychostimulant addiction and schizophrenia.- Intraseptal cholinergic infusions alter memory in the rat: method and mechanism.-Modulation of visual perception and action by forebrain structures and their interactions in amphibians.- Neuromodulators of LTP and NCAMs in the amygdala and hippocampus in response to stress.- Central histaminergic system interactions and cognition.- Cholinergic, histaminergic, and noradrenergic regulation of LTP stability and induction threshold: cognitive implications.- Nicotinic-antipsychotic drug interactions and cognitive function.- Function and dysfunction of monoamine interactions in children and adolescents with ADHD.- Prepulse inhibition mechanisms and cognitive processes: a review and model.