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Chemokine Biology - Basic Research and Clinical Application

Vol. 2: Pathophysiology of Chemokines

  • Book
  • © 2007

Overview

Editors:
  1. Kuldeep Neote

    1. Lilly Corporate Center, Cancer Inflammation and Cell Survival Eli Lilly and Company, Indianapolis, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Gordon L. Letts

    1. NitroMed, Inc., Bedford, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Bernhard Moser

    1. Theodor Koch Institute, University of Bern, Bern, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

  • Comprehensive and up-to-date overview of the field
  • Both volumes complement each other, but can also be used independently from each other
  • Written by leading experts in the field
  • The volume editors organized several international conferences on chemokines
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xii
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  2. Chemokines in animal disease models

    1. Front Matter

      Pages 1-1
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    2. Chemokines in animal models of inflammation

      • Steven L. Kunkel, Nuria Godessart, Cory Hogaboam, Stephen W. Chensue, Nicholas Lukacs
      Pages 3-17

    3. Autoimmune diseases

      • William J. Karpus
      Pages 19-26

    4. Chemokines in allergic responses: eosinophils, basophils, mast cells

      • Zamaneh Mikhak, Andrew D. Luster
      Pages 27-41

  3. Chemokines as drug targets

    1. Front Matter

      Pages 43-43
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    2. Chemokines as drug targets

      • Amanda E. I. Proudfoot, Christine A. Power, Matthias Schwarz, Timothy N. C. Wells
      Pages 45-59

    3. Screening and characterization of cyclic pentapeptide CXCR4 antagonists/inverse agonists using a pheromone responsive reporter gene in Saccharomyces cerevisiae: Utility of G protein coupled receptor constitutively active mutants

      • Zi-xuan Wang, Hirokazu Tamamura, Nicole Frilot, James Broach, Nobutaka Fujii, Stephen C. Peiper
      Pages 61-77

    4. Antagonists of CXCR3: a review of current progress

      • Tassie L. Collins, Michael G. Johnson, Julio C. Medina
      Pages 79-88

    5. IL-8 receptor antagonist: basic research and clinical utility

      • John R. White, Henry M. Sarau
      Pages 89-102

    6. Current status of CCR1 antagonists in clinical trials

      • Ronald P. Gladue, Matthew F. Brown
      Pages 103-113

    7. Small molecule CCR2 antagonists

      • Paul J. Higgins, C. Eric Schwartz, Jean-Marie Nicolas
      Pages 115-123

    8. Chemokine axes in hematopoietic stem cell mobilization

      • Louis M. Pelus, Hal E. Broxmeyer
      Pages 125-144

    9. CCR5 antagonists: from discovery to clinical efficacy

      • Shon R. Pulley
      Pages 145-163

  4. Back Matter

    Pages 165-170
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Keywords

About this book

Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV.
Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.

Editors and Affiliations

  • Lilly Corporate Center, Cancer Inflammation and Cell Survival Eli Lilly and Company, Indianapolis, USA

    Kuldeep Neote

  • NitroMed, Inc., Bedford, USA

    Gordon L. Letts

  • Theodor Koch Institute, University of Bern, Bern, Switzerland

    Bernhard Moser

Bibliographic Information

  • Book Title: Chemokine Biology - Basic Research and Clinical Application

  • Book Subtitle: Vol. 2: Pathophysiology of Chemokines

  • Editors: Kuldeep Neote, Gordon L. Letts, Bernhard Moser

  • Series Title: Progress in Inflammation Research

  • DOI: https://doi.org/10.1007/978-3-7643-7437-2

  • Publisher: Birkhäuser Basel

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Birkhäuser Basel 2007

  • Hardcover ISBN: 978-3-7643-7195-1Published: 17 April 2007

  • eBook ISBN: 978-3-7643-7437-2Published: 08 August 2007

  • Series ISSN: 1422-7746

  • Series E-ISSN: 2296-4525

  • Edition Number: 1

  • Number of Pages: XII, 171

  • Topics: Immunology, Pharmacology/Toxicology, Cell Biology

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