Cancer: Cell Structures, Carcinogens and Genomic Instability

1. Front Matter

   Pages I-XI

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2. Cancer morphology, carcinogenesis and genetic instability: a background

   • Leon P. Bignold, B. L. D. Coghlan, H. P. A. Jersmann

   Pages 1-24

3. Abnormalities of chromatin in tumor cells

   • Bojan Drobic, Katherine L. Dunn, Paula S. Espino, James R. Davie

   Pages 25-47

4. Aneuploidy, stem cells and cancer

   • Sen Pathak, Asha S. Multani

   Pages 49-64

5. The mode of action of organic carcinogens on cellular structures

   • Andreas Luch

   Pages 65-95

6. Metal ions and carcinogenesis

   • Troy R. Durham, Elizabeth T. Snow

   Pages 97-130

7. Actions of ultraviolet light on cellular structures

   • David I. Pattison, Michael J. Davies

   Pages 131-157

8. Actions of radiation on living cells in the “post-bystander” era

   • Carmel Mothersill, C. B. Seymour

   Pages 159-177

9. Viral carcinogenesis and genomic instability

   • Karl Münger, Hiroyuki Hayakawa, Christine L. Nguyen, Nadja V. Melquiot, Anette Duensing, Stefan Duensing

   Pages 179-199

10. Abnormalities of cell structures in tumors: apoptosis in tumors

    • Herman H. Cheung, Vinay Arora, Robert G. Korneluk

    Pages 201-221

11. Molecular regulation of tumor angiogenesis: mechanisms and therapeutic implications

    • Jay Harper, Marsha A. Moses

    Pages 223-268

12. Genetic and environmental factors in hereditary predisposition to tumors: a conceptual overview

    • Okio Hino, Toshiyuki Kobayashi, Kazuo Okimoto

    Pages 269-292

13. Effects of ionizing radiation on cellular structures, induced instability and carcinogenesis

    • Marianne Sowa, Benjamin J. Arthurs, Brian J. Estes, William F. Morgan

    Pages 293-301

14. Genetic instability in human tumors

    • Stavroula Raptis, Bharati Bapat

    Pages 303-320

15. Molecular mechanisms of human carcinogenesis

    • William B. Coleman, Gregory J. Tsongalis

    Pages 321-349

16. Mechanisms of abnormal gene expression in tumor cells

    • Assam El-Osta

    Pages 351-361

17. Back Matter

    Pages 363-376

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This volume began with an invitation from the publishers to edit a volume of EXS on Cancer. This invitation undoubtedly derived from my articles in Cellular and Molecular Life Sciences in 2002 and 2003 on the relationships between the morphology, aetiology and pathogenesis of tumours, especially in relation to genetic instability. After many years of teaching the theories of c- cer in undergraduate medical school courses, it seemed to me that the variably chaotic histopathologic features of tumours parallel in some way, the variably unstable genomes of tumour cells, which were being discovered in the 1990s. Thus the title of the volume has come to include morphology, carcinogenesis and genetic instability. The invitation came while I was working with Herrn Dr. med. Hubertus Jersmann (MD Düsseldorf, PhD, now Senior Lecturer in Medicine of the University of Adelaide) and Professor Brian Coghlan (Emeritus Professor of German, the University of Adelaide), on the work of the nineteenth century cancer pathologists, especially David Paul von Hansemann (1858–1920). With the delivery of the manuscripts from the authors of the chapters, it became obvious that a background chapter for the volume could include some of the material which we had “uncovered” together. Because of this, chapter 1 is authored by the three of us, and the “new” material figures prominently.

• angiogenesis
• animals
• apoptosis
• behavior
• cancer
• cancer research
• carcinogenesis
• cell
• gene expression
• genes
• genome
• pathogenesis
• prevention
• regulation
• tumor

• University of Adelaide Dept. Pathology, Adelaide, Australia

  Leon P. Bignold

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