Overview
- Links the remodeling process with the biosynthesis of mediators of inflammation and diseases
- Provides a new perspective by following the movement of the substrate (AA) rather than discussing single enzymes and their related mediators
- International authorship
Part of the book series: Progress in Inflammation Research (PIR)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (11 chapters)
Keywords
About this book
Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation. Thus, PUFA remodeling is a critical process in the biosynthesis of a multitude of mediators, and understanding this process will unravel better therapeutic targets for controlling inflammatory diseases such as asthma and Alzheimer’s disease.
AA metabolism is described in an integrated context linking the remodeling processes with the biosynthesis of mediators and diseases. By following the movement of the substrate (AA), the volume describes how upstream biosynthetic pathways influence the formation of lipid mediators of inflammation, showing the metabolic interrelationship between all AA-derived mediators.
Editors and Affiliations
Bibliographic Information
Book Title: Arachidonate Remodeling and Inflammation
Editors: Alfred N. Fonteh, Robert L. Wykle
Series Title: Progress in Inflammation Research
DOI: https://doi.org/10.1007/978-3-0348-7848-7
Publisher: Birkhäuser Basel
-
eBook Packages: Springer Book Archive
Copyright Information: Birkhäuser Verlag 2004
Hardcover ISBN: 978-3-7643-6948-4Published: 27 November 2003
Softcover ISBN: 978-3-0348-9594-1Published: 21 October 2012
eBook ISBN: 978-3-0348-7848-7Published: 06 December 2012
Series ISSN: 1422-7746
Series E-ISSN: 2296-4525
Edition Number: 1
Number of Pages: XI, 243
Topics: Immunology, Pharmacology/Toxicology, Medical Biochemistry, Internal Medicine, Rheumatology, Cell Biology