GABA: Receptors, Transporters and Metabolism

1. Front Matter

   Pages I-X

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2. Opening lecture

   1. Establishment of GABA as an Inhibitory Neurotransmitter at Crustacean Neuromuscular Junction and in the Mammalian Central Nervous System

      • M. Otsuka

      Pages 1-6

3. Glutamate decarboxylase and autoimmunity

   1. Physiological Aspects of GAD-GABA System in the Pancreatic Islet

      • Hiroshi Taniguchi, Junichi Katoh, Motoyoshi Sakaue, Yasuhiro Okada

      Pages 7-12

   2. Membrane Associated L-Glutamate Decarboxylase and Insulin-Dependent Diabetes Mellitus (IDDM)

      • J.-Y. Wu, B. Nathan, C.-C. Hsu, C.-Y. Kuo, G. A. Burghen, R. Wu et al.

      Pages 13-22

   3. Glutamate Decarboxylase, GABA and Autoimmunity

      • Allan J. Tobin, Daniel L. Kaufman

      Pages 23-30

   4. Stiff-Man Syndrome and Glutamic Acid Decarboxylase: An Updated View

      • M. Solimena, R. Dirkx, M. Butler, J.-M. Hermel, J. Guernaccia, K. Marek et al.

      Pages 31-43

   5. Anti-GAD Antibody in Various Neurological Diseases

      • Shigenobu Nakamura, Hidekazu Kamei, Yasuyo Mimori

      Pages 45-52

4. Molecular structure and functional regulation of GABA transporters

   1. GABA Transporters: Structure, Function and Mechanism

      • Baruch I. Kanner

      Pages 53-61

   2. Heterogeneity of Brain GABA Transporters

      • Kelli E. Smith, Eric L. Gustafson, Laurence A. Borden, T. G. Murali Dhar, Margaret M. Durkin, Pierre J.-J. Vaysse et al.

      Pages 63-72

   3. Developmental Expression of the GABA Transporter GAT4

      • Frantisek Jursky, Nathan Nelson

      Pages 73-82

   4. Functional Regulation of GABA Transporters by PKC and their Distinct Localization

      • Naoaki Saito, Chikako Tanaka

      Pages 83-93

5. Transmitter release and GABA receptor regulation

   1. GABAB Receptor Control of Transmitter Release in the Spinal Cord

      • H. Teoh, M. Malcangio, N. G. Bowery

      Pages 95-102

   2. Role of GABAA and GABAB Receptors in Ca++ Homeostasis and Transmitter Release in Cerebellar Granule Neurons

      • Arne Schousboe, Lisbeth Elster, Inge Damgaard, Henrik Pallos, Povl Krogsgaard-Larsen, Julianna Kardos

      Pages 103-113

   3. Interactions between Endogenous L-DOPA and GABA_A Systems for Cardiovascular Control in the Rat Nucleus Tractus Solitarii

      • Yoshimi Misu, Jin-Liang Yue, Yoko Okumura, Takeaki Miyamae, Yoshio Goshima

      Pages 115-121

   4. Potentiation by Protein Kinase C Activation of GABA Release from Xenopus Oocytes Injected with Rat Brain mRNA

      • Y. Kataoka, S. Kan, S. Mameya, H. Shibaguchi, K. Yamashita, M. Niwa et al.

      Pages 123-127

6. GABA receptor subtypes and functional regulation

   1. The Molecular Biology of GABAA Receptors and Its Applications

      • Eric A. Barnard

      Pages 129-143

   2. Modelling Functional Domains of the GABAA Receptor Chloride Channel

      • R. W. Olsen, G. B. Smith, S. Srinivasan

      Pages 145-155

   3. GABA_A-Receptor Subtypes: Pharmacological Significance and Mutational Analysis in Vivo

      • H. Mohler, J. M. Fritschy, D. Benke, J. Benson, U. Rudolph, B. Lüscher

      Pages 157-171

   4. Regulation of GABAA Receptors by Multiple Protein Kinases

      • Stephen J. Moss, Bernard McDonald, George H. Gorrie, Belinda K. Krishek, Trevor G. Smart

      Pages 173-184

   5. Enhancement of GABA-Induced Current by 20-Hydroxy- Ecdysone in Cultured Cortical Neurons

      • M. Sasa, S. Tsujiyama, K. Ishihara, R. Hanaya, M. Fujita, K. Kurisu et al.

      Pages 185-194

Highlighting the current developments and future directions in GABA research, the ambitious aim of this topical volume is to cover GABA from the molecular mechanisms of its transmission to new targets for pharmaceutical research. Distinguished scientists at the forefront of GABA research were invited to contribute reviews on glutamate decarboxylase and autoimmunity, molecular structure and functional regulation of GABA transporters, transmitter release and GABA receptor regulation, GABA receptor subtypes and functional regulation, and GABA receptor ligands and their therapeutic application. Describing the latest advances in what has become a rapidly-evolving field, this volume will prove immensely valuable to neuroscientists, pharmacologists, biochemists, and physiologists working in the field of GABA research.

• Calcium
• GABA
• Glutamat
• Nervous System
• biology
• central nervous system
• development
• immunity
• metabolism
• neurons
• neuroscience
• neurotransmitter
• receptor
• research
• transcription

• Hyogo Institute for Aging Brain and Cognitive Disorders, Kobe University, Himeji Hyogo, Japan

  Chikako Tanaka

• The Medical School, University of Birmingham, Edgbaston Birmingham, UK

  Norman G. Bowery

Policies and ethics