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Combination Therapy of AIDS

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  • © 2004
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Overview

Editors:
  1. Erik D. A. Clercq

    1. Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium

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    You can also search for this editor in PubMed   Google Scholar

  2. Anne-Mieke I. Vandamme

    1. Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium

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    You can also search for this editor in PubMed   Google Scholar

  • Authored by leading scientists
  • Excellent overview of the topic
  • Comprehensive, well structured
  • Includes supplementary material: sn.pub/extras

Part of the book series: Milestones in Drug Therapy (MDT)

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Table of contents (14 chapters)

  1. Front Matter

    Pages I-XI
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  2. Anti-HIV agents to be used in drug combination regimens

    • Erik De Clercq
    Pages 1-23
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  3. A perspective of the history of HAART

    • Deborah Konopnicki, Nathan Clumeck
    Pages 25-40
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  4. The basic principles for combination therapy

    • Cécile L. Tremblay, Martin S. Hirsch
    Pages 41-51
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  5. Comparison of the efficacy of HAART: single, dual or triple-class antiretroviral therapy

    • Roger Paredes, Bonaventura Clotet, Lidia Ruiz
    Pages 53-71
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  6. Pharmacokinetics and pharmacodynamics of HAART

    • Michael Kurowski
    Pages 73-86
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  7. Primary HIV infection: from diagnosis to treatment

    • Luc Perrin, Marie-Charlotte Bernard
    Pages 87-98
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  8. Salvage therapy

    • Marianne Harris, Julio S. G. Montaner
    Pages 99-113
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  9. Structured therapy interruptions (STIs): lessons from a therapeutic strategy

    • Felipe García, Joan Joseph, José M. Gatell
    Pages 115-126
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  10. Immune reconstitution in HIV infection

    • Brigitte Autran
    Pages 127-140
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  11. Highly active antiretroviral treatment (HAART) of pediatric HIV-1 infection

    • Nicole T. Tobin, Lisa M. Frenkel
    Pages 141-157
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  12. Causes of HIV treatment failure

    • Roy M. Gulick
    Pages 159-194
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  13. Economic implication of HIV-1 resistance testing in overall clinical care

    • Christopher Holtzer, Mike Youle
    Pages 195-204
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  14. Guidelines for antiretroviral therapy

    • Charles C. J. Carpenter
    Pages 205-223
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  15. Visions for the future of antiretroviral therapy

    • Ume L. Abbas, John W. Mellors
    Pages 225-237
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  16. Back Matter

    Pages 239-243
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Keywords

About this book

HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica­ tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro­ longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system.

Editors and Affiliations

  • Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium

    Erik D. A. Clercq, Anne-Mieke I. Vandamme

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