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Arachidonate Remodeling and Inflammation

  • Book
  • © 2004

Overview

Editors:
  1. Alfred N. Fonteh

    1. Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Robert L. Wykle

    1. Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Links the remodeling process with the biosynthesis of mediators of inflammation and diseases
  • Provides a new perspective by following the movement of the substrate (AA) rather than discussing single enzymes and their related mediators
  • International authorship

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xi
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  2. An outline of arachidonate remodeling and its biological significance

    • Alfred N. Fonteh
    Pages 1-11

  3. Phospholipase A2 and remodeling in inflammatory cells

    • Suzanne E. Barbour, Salma Al-Darmaki, Alex D. Manguikian
    Pages 13-36

  4. Enzymatic and receptor mediated effects of secretory phospholipase A2 on the pathophysiology of inflammatory diseases

    • Chad R. Marion, Alfred N. Fonteh
    Pages 37-60

  5. Control of arachidonic acid levels in resting and activated U937 phagocytic cells by Ca2+-independent phospholipase A2

    • Jesús Balsinde, Rebeca Pérez, Yolanda Sáez, María A. Balboa
    Pages 61-72

  6. Arachidonate remodeling and PAF synthesis in human neutrophils

    • Robert L. Wykle
    Pages 73-87

  7. Control of long chain polyunsaturated fatty acid levels and the role of inhibitors of incorporation and remodeling on the biosynthesis of lipid mediators

    • Allen M. McAlexander, Brooke J. Barham, Margaret Johnson, Alfred N. Fonteh
    Pages 89-113

  8. Remodeling of arachidonic acid in inflammatory cells of the human lung

    • Massimo Triggiani, Giorgio Giannattasio, Francescopaolo Granata, Stefania Loffredo, Francesca W. Rossi, Salvatore Salzano et al.
    Pages 115-130

  9. Arachidonate remodeling, platelet-activating factor signaling, and the inflammatory response in the central nervous system

    • Royal D. Saunders, Nicolas G. Bazan
    Pages 131-143

  10. Remodeling of arachidonate and other polyunsaturated fatty acids in Alzheimer’s disease

    • Alfred N. Fonteh, Michael G. Harrington
    Pages 145-167

  11. Lipoxins and resolvins: Local mediators in endogenous anti-inflammation and resolution

    • Charles N. Serhan, Nan Chiang
    Pages 169-210

  12. Metabolism and physiological significance of anandamide and 2-arachidonoylglycerol, endogenous cannabinoid receptor ligands

    • Takayuki Sugiura, Seishi Kishimoto, Saori Oka, Maiko Gokoh, Keizo Waku
    Pages 211-237

  13. Back Matter

    Pages 239-243
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Keywords

About this book

Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation. Thus, PUFA remodeling is a critical process in the biosynthesis of a multitude of mediators, and understanding this process will unravel better therapeutic targets for controlling inflammatory diseases such as asthma and Alzheimer’s disease.
AA metabolism is described in an integrated context linking the remodeling processes with the biosynthesis of mediators and diseases. By following the movement of the substrate (AA), the volume describes how upstream biosynthetic pathways influence the formation of lipid mediators of inflammation, showing the metabolic interrelationship between all AA-derived mediators.

Editors and Affiliations

  • Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, USA

    Alfred N. Fonteh

  • Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, USA

    Robert L. Wykle

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