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Birkhäuser - Birkhäuser BioSciences | Effects of Nicotine on Biological Systems II

Effects of Nicotine on Biological Systems II

Clarke, P., Quik, M., Adlkofer, F., Thurau, K. (Eds.)

Softcover reprint of the original 1st ed. 1995, XI, 407 p.

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Content Level » Research

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Table of contents 

I: Overview.- Current controversies in nicotine research.- Acute biological effects of nicotine and its metabolites.- Involvement of nicotine and its metabolites in the pathology of smoking-related diseases: Facts and hypotheses.- II. Structure and function of nicotinic receptors.- A cyclophilin-dependent mechanism for ?7 neuronal nicotinic acetylcholine receptor maturation.- ?-Bungarotoxin receptor subtypes.- Neuronal nicotinic receptor structure and function.- Determinants regulating neuronal nicotinic receptor function.- Expression, function, and regulation of neuronal acetylcholine receptors containing the ?7 gene product.- III. Nicotinic receptor regulation and tolerance.- Biochemical measures of nicotinic receptor desensitization.- The role of desensitization in CNS nicotinic receptor function.- Presynaptic nicotinic autoreceptors and heteroreceptors in the CNS.- Regulation of neuronal nicotinic receptors in primary cultures.- Conditioned tolerance to nicotine in rats.- IV: Neuronal, trophic and endocrine effects of nicotine.- Developmental effects of nicotine.- Presynaptic nicotine-gated channels potentiate transmission at ACh and glutamate-mediated synapses.- Electrophysiology of neuronal nicotinic receptors in the CNS.- Factors controlling nicotinic acetylcholine receptor expression on rat sympathetic neurons.- Growth related role for the nicotinic ?-bungarotoxin receptor.- Mechanisms of nicotine stimulated cell proliferation in normal and neoplastic neuro-endocrine lung cells.- Activation of the hypothalamic-pituitary-adrenal axis by nicotine: Neurochemical and neuroanatomical substrates.- Regulation of proenkephalin gene expression in bovine adrenal medullary chromaffin cells by nicotine.- Effects of nicotine on thromboxane and leukotriene synthesis in cellular systems.- V: Nicotine and smoking: Current controversies.- Smoking-induced alterations in brain electrical profiles: Normalization or enhancement?.- Nicotine and cognitive effects.- Evidence that nicotine is addictive.- Self-administered nicotine acts through the ventral tegmental area: Implications for drug reinforcement mechanisms.- Desensitisation of the stimulatory effects of nicotine on dopamine secretion in the mesolimbic system of the rat.- Nicotine as a discriminative stimulus: Individual variability to acute tolerance and the role of receptor desensitization.- Behavioral and biochemical analysis of the dependence properties of nicotine.- Nicotine boost per cigarette as the controlling factor of intake regulation by smokers.- There is more to smoking than the CNS effects of nicotine.- Pharmacological determinants of cigarette smoking.- The functional conception of nicotine use.- Nicotine is addictive: The issue of free choice.- Differentiating habits and addictions: The evidence that nicotine is not ‘addictive’.- Differences in response to nicotine are determined by genetic factors.- VI: Nicotine and human diseases.- Relationship between smoking, nicotine and ulcerative colitis.- Transdermal nicotine in Tourette’s syndrome.- Nicotine and neuropsychiatric disorders: Schizophrenia.- Nicotinic receptors and the pathophysiology of schizophrenia.- The epidemiology of cigarette smoking and Parkinson’s disease.- Nicotine and animal models of Parkinson’s disease.- Nicotine effects on memory performance.- Possible mechanisms underlying beneficial effects of nicotine on cognitive function.- Nicotinic modulation of cognitive functioning in humans.- Invited Contributions.- Distribution of nicotinic acetylcholine receptor subunit immunoreactivities on the surface of chick ciliary ganglion neurons.- Autoradiographic distribution of nicotinic receptor sites labelled with [3H]cytisine in the human brain.- Epibatidine.- Measuring changes in mesolimbic dopamine and related substances in response to systemic nicotine using in vivo electrochemistry.- Effect of nicotine and cotinine on NNK metabolism in rats.- Concluding Remarks: The future of nicotine-containing products.- Author Index.

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