Assembly of the Vasculature and Its Regulation

1. Front Matter

   Pages i-xvii

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2. The Development of Blood Vessels: Cellular and Molecular Mechanisms

   • Peter Carmeliet

   Pages 1-20

3. The Role of Vascular Endothelial Growth Factors and Their Receptors During Embryonic Vascular Development

   • Ingo Flamme, Georg Breier

   Pages 21-54

4. The Ties That Bind: Emerging Concepts About the Structure and Function of Angiopoietins and Their Receptors in Angiogenesis

   • Chitra Suri, George D. Yancopoulos

   Pages 55-66

5. Extracellular Matrix in the Regulation of Angiogenesis

   • Jingsong Xu, Peter C. Brooks

   Pages 67-95

6. The Role of Cell Adhesion Receptors in Vascular Development: An Overview

   • Paul Robson, Susan Pichla, Bin Zhou, H. Scott Baldwin

   Pages 97-110

7. Development and Differentiation of Vascular Smooth Muscle

   • Mark W. Majesky, Xiu-Rong Dong, Jun Lu

   Pages 111-131

8. Vascular Development of the Heart

   • Robert J. Tomanek, Xinping Yue, Wei Zheng

   Pages 133-155

9. Vascular Development of the Brain and Spinal Cord

   • Haymo Kurz, Bodo Christ

   Pages 157-191

10. Vascular Development of the Kidney

    • R. Ariel Gómez, María Luisa S. Sequeira López

    Pages 193-210

11. Vascular Development of the Lung

    • Daphne E. deMello, Lynne M. Reid

    Pages 211-237

12. Vascularization of the Placenta

    • Ronald J. Torry, Joanna Schwartz, Donald S. Torry

    Pages 239-273

13. Back Matter

    Pages 275-279

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The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progressively and irreversibly assemble into a segmented, primary heart tube that can be remodeled into a four-chambered organ, and (2) how blood vessels are derived and assembled both in the heart and in the body. Our central aim is to establish a four-dimensional, spatiotemporal foundation for the heart and blood vessels that can be genetically dissected for function and mechanism. Since Robert DeHaan's seminal chapter "Morphogenesis of the Vertebrate Heart" published in Organogenesis (Holt Rinehart & Winston, NY) in 1965, there have been surprisingly few books devoted to the subject of cardiovascular mor­ phogenesis, despite the enormous growth of interest that occurred nationally and internationally. Most writings on the subject have been scholarly compilations of the proceedings of major national or international symposia or multiauthored volumes, often without a specific theme. What is missing are the unifying concepts that can make sense out of a burgeoning database of facts. The Editorial Board of this new series believes the time has come for a book series dedicated to cardio­ vascular morphogenesis that will serve not only as an important archival and didac­ tic reference source for those who have recently come into the field but also as a guide to the evolution of afield that is clearly coming of age.

• biology
• brain
• cell
• cell biology
• central nervous system
• development
• developmental biology
• embryo
• migration
• molecular mechanisms
• placenta
• regulation

• Department of Anatomy and Cell Biology, University of Iowa, Iowa City, USA

  Robert J. Tomanek

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