Alzheimer Disease

Pathological Basis of Therapy in Alzheimer Disease

1. Front Matter

   Pages 1-1

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2. Criteria for the Diagnosis of Alzheimer’s Disease

   1. Criteria for the Clinical Diagnosis of Alzheimer’s Disease: Transcultural Aspects

      • Luigi Amaducci, Marzia Baldereschi

      Pages 3-6

   2. Clinical and Neuropathological Findings from CERAD

      • John C. Morris

      Pages 7-11

   3. Differentiating Alzheimer Disease and Vascular Dementia: Reframing the Question

      • Helena Chui, Qian Zhang, Jeff Victoroff, Barbara Zaias

      Pages 13-17

3. Neuropathology Of Alzheimer’s Disease

   1. Basis of Structural Alzheimer Disease and Some Pathogenic Concepts

      • Robert D. Terry

      Pages 19-23

   2. Regional Distribution of Neuropathological Changes in Alzheimer’s Disease

      • Constantin Bouras, Pandelis Giannakopoulos, Philippe G. Vallet

      Pages 25-29

   3. Alzheimer Neurofibrillary Degeneration: A Feasible and Key Target for Therapeutics

      • Khalid Iqbal, Alejandra C. del Alonso, Cheng-Xin Gong, Niloufar Haque, Sabiha Khatoon, Takashi Kudo et al.

      Pages 31-36

   4. Diabetes and Dementia: A Retrospective Neuropathologic Study of Old Diabetics Compared to Non-Diabetic Controls

      • Jean-Pierre Michel, Pius Muller, Gabriel Gold, Willliam Mac Gee, Reihnild Mulligan, Constantin Bouras

      Pages 37-46

4. Processing of Amyloid, Cytoskeletal Damage and Apolipoproteins

   1. Isoform-Specific Metabolism of Apolipoprotein E: Implications for Alzheimer ’s Disease

      • Warren J. Strittmatter

      Pages 47-53

   2. Apolipoprotein E4 and Cholinergic Activity in Alzheimer’s Disease

      • Judes Poirier, Isabelle Aubert, Rémi Quirion, Serge Gauthier, Martin Farlow, Josephine Nalbantoglu et al.

      Pages 55-60

   3. A New Focus on Cytoskeletal Therapy in Alzheimer’s Disease

      • Hugo Geerts, Rony Nuydens, Mirjam de Jong, Gerd van de Kieboom

      Pages 61-65

   4. Novel Cathepsin D Inhibitors Prevent the β-Secretase-Derived Intracellular Formation of a 12 kDa Potentially Amyloidogenic Product in Human Cells

      • Nathalie Chevallier, Philippe Marambaud, Jean-Pierre Vincent, Frédéric Checler, Jean Vizzavona, Pierre Fulcrand et al.

      Pages 67-73

   5. Cellular and Test Tube Models of Amyloid-βFormation

      • Henryk M. Wisniewski, Janusz Frackowiak, Bozena Mazur-Kolecka, Jerzy Wegiel, Abha Chauhan, Ved P. S. Chauhan

      Pages 75-80

   6. Effects of β-Amyloid (1–40) Peptide Injection in the Nucleus Basalis

      • Giancarlo Pepeu, Lisa Giovannelli, Fiorella Casamenti, Carla Scali

      Pages 81-85

   7. ß-Amyloid Precursor Protein — Role in Cognitive Brain Function?

      • Gerda S. Huber, Jean-Luc Moreau, James R. Martin, Yannick Bailly, Jean Mariani, Bernard Brugg

      Pages 87-90

   8. Peptides Inhibitor of Amyloidogenesis in Alzheimer’s Disease

      • Claudio Soto, Frances Prelli, Blas Frangione, Mark S. Kindy, Frederick de Beer

      Pages 91-97

5. Cell Death: Excitotoxins, Apoptosis and Hypometabolism

   1. Apoptosis and Alzheimer’s Disease: A Self-Assembly and the Initiation of Apoptosis by Plasma Membrane Receptor Cross-Linking

      • C. W. Cotman, D. H. Cribbs, J. H. Su

      Pages 99-106

   2. NMDA Receptor Dysfunction in Alzheimer’s Disease

      • John Olney, David Wozniak, Masahiko Ishimaru, Nuri Färber

      Pages 107-112

   3. Role of Neuron-Glia Interactions in Brain Energy Metabolism: Implications for Neurodegenerative Disorders

      • Pierre J. Magistretti, Philippe Bittar, Luc Pellerin

      Pages 113-118