Logo - springer
Slogan - springer

Biomedical Sciences - Virology | Sendai Virus Vector - Advantages and Applications

Sendai Virus Vector

Advantages and Applications

Nagai, Yoshiyuki (Ed.)

2013, XII, 210 p. 33 illus., 17 illus. in color.

Available Formats:

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.


(net) price for USA

ISBN 978-4-431-54556-9

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase

learn more about Springer eBooks

add to marked items


Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.


(net) price for USA

ISBN 978-4-431-54555-2

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days

add to marked items

  • Comprehensively reviews the development of SeV vector, a multipurpose cytoplasmic (non-integrating) RNA vector with extremely high performance
  • Describes advanced devices such as transmissibility-deficient or replication-incompetent safer versions and a “footprint (transgene) free” expression system
  • Illustrates diverse applications with high medical impact

Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.

Content Level » Research

Keywords » Gene therapy - Nonsegmented negative strand RNA virus - Sendai virus (SeV) - Transgene - Vector development - Viral vectors - iPS - transduction

Related subjects » Human Genetics - Virology

Table of contents 

1. Reverse genetics of Mononegavirales: the rabies virus paradigm.-2. Sendai virus biology and engineering leading up to the development of a novel class of expression vector.-3. Concept and technology underlying Sendai virus (SeV) vector development.-4. Roadmap for development of a replication-deficient Sendai virus vaccine vector (provisional).-5. Development of vaccines using SeV vectors against AIDS and other infectious diseases.-6. BioKnife, a modified Sendai virus, to resect malignant tumors.-7. Induction of human pluripotent stem cells by the Sendai virus vector:Establishment of a highly efficient and foot-print free system.- 8. Gene therapy for peripheral arterial disease using Sendai virus vector: From preclinical Studies to the phase I/IIa clinical trial

Popular Content within this publication 



Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Virology.