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Transforming Proteins of DNA Tumor Viruses

  • Conference proceedings
  • © 1989

Overview

Editors:
  1. Rolf Knippers

    1. Fakultät für Biologie, Universität Konstanz, Konstanz, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Arnold J. Levine

    1. Department of Biology, Princeton University, Princeton, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 144)

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Table of contents (33 papers)

  1. Front Matter

    Pages I-XIV
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  2. The Transforming Protein of Simian Virus 40: Large T Antigen and Its Interaction with the Cellular Protein p 53

    1. Front Matter

      Pages 1-1
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    2. Introduction

      • Rolf Knippers, Arnold J. Levine
      Pages 3-7

    3. Structure and Function of SV40 Large T Antigen Communication Between Functional Domains

      • E. Fanning, J. Schneider, A. Arthur, A. Höss, I. Moarefi, S. Modrow
      Pages 9-19

    4. A Genetic Analysis of the Zinc Finger of SV40 Large T Antigen

      • G. Loeber, R. Parsons, P. Tegtmeyer
      Pages 21-29

    5. Effects of Amino Acid Phosphorylation on the DNA Binding Properties of Large T Antigen

      • K. Klausing, R. Knippers
      Pages 31-35

    6. SV40 T Antigen Catalyzed Duplex DNA Unwinding

      • M. Scheffner, R. Wessel, H. Stahl
      Pages 37-45

    7. Control of Transcription in Vitro from Simian Virus 40 Promoters by Proteins from Viral Minichromosomes

      • P. Beard, H. Bruggmann
      Pages 47-54

    8. Dissection of the T Antigen/Mouse p53 Complex and Its Inhibitory Effects on Viral Origin-Directed DNA Replication in Vivo and in Vitro

      • H.-W. Stürzbecher, K. Rudge, R. Brain, C. Addison, M. Grimaldi, J. R. Jenkins
      Pages 55-62

    9. Interactions Between SV40 and Cellular Oncogenes in the Transformation of Primary Rat Cells

      • D. Michalovitz, A. Amsterdam, M. Oren
      Pages 63-75

    10. Metabolic Stabilization of p53 in SV40-Transformed Cells Correlates with Expression of the Transformed Phenotype but is Independent from Complex Formation with SV40 Large T Antigen

      • W. Deppert, T. Steinmayer
      Pages 77-83

    11. SV40 Large T Antigen Induces a Protein Kinase Responsible for Phosphorylation of the Cellular Protein p53

      • K. H. Scheidtmann
      Pages 85-88

    12. Evidence for Threshold Effects in Transformation of Pancreatic β Cells by SV40 T Antigen in Transgenic Mice

      • S. Efrat, D. Hanahan
      Pages 89-95

    13. The Biological Activity of Early SV40 Antisense RNA and DNA Molecules

      • M. Graessmann, A. Graessmann
      Pages 97-103

  3. Polyoma Virus Middle T Antigen

    1. Front Matter

      Pages 105-105
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    2. Introduction

      • Rolf Knippers, Arnold J. Levine
      Pages 107-108

    3. Mechanism of Activation of Complexed pp60c-src by the Middle T Antigen of Polyomavirus

      • S. H. Cheng, R. Harvey, H. Piwnica-Worms, P. C. Espino, T. M. Roberts, A. E. Smith
      Pages 109-120

    4. Further Characterisation of the Complex Containing Middle T Antigen and pp60

      • S. A. Courtneidge
      Pages 121-128

    5. The Mutagenic and Immortalizing Potential of Polyoma virus Large T Antigen

      • M. Strauss, L. Lübbe, U. Kiessling, M. Platzer, B. E. Griffin
      Pages 129-134

  4. Transforming Functions of Papillomaviruses

    1. Front Matter

      Pages 135-135
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Keywords

About this book

It is surprising, and even disappointing, that there have been very few meetings and published volumes resulting from these meetings that focus attention upon all of the groups of DNA tumor viruses. Historically, separate meetings were held each year for the adenovirus-SV40-polyoma researchers, the herpes­ viruses, hepatitis B virus and the papillomaviruses. It was as if these four virus groups were four fields of study developing independently with a literature and culture of their own. When a virologist crossed the field from the adenovirus group to the herpesvirus or papillomaviruses, he or she was lost to their former group because of the structure of separate meetings and remote literature. This, of course, has resulted from historical accident and is being rectified by the rapid progress made in our understanding of how these viruses contribute to the causation of cancer in animals and humans. It was pre­ cisely because of these factors that it was time to hold a meeting and publish its proceedings on the subject of transforming proteins of DNA tumor viruses. For the first time, DNA tumor viruses were defined as all of the virus groups that can contribute to cancer in animals with the exception, unfortunately, of the . poxviruses. The purpose of the meeting was to bring together scientists who rarely attend meetings together but actually work on the same problems with different viruses.

Editors and Affiliations

  • Fakultät für Biologie, Universität Konstanz, Konstanz, Germany

    Rolf Knippers

  • Department of Biology, Princeton University, Princeton, USA

    Arnold J. Levine

Bibliographic Information

  • Book Title: Transforming Proteins of DNA Tumor Viruses

  • Editors: Rolf Knippers, Arnold J. Levine

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-74578-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1989

  • Softcover ISBN: 978-3-642-74580-5Published: 16 December 2011

  • eBook ISBN: 978-3-642-74578-2Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIV, 284

  • Topics: Virology, Medical Microbiology, Oncology

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