Softcover reprint of the original 1st ed. 2001, XI, 296 p.
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Marek's disease virus (MDV) is a herpesvirus which causes a lymphoproliferative disorder of the domestic chicken worldwide. The serious economical problem caused by MDV was mostly solved by development of an effective vaccine against MDV. The development of live vaccines against the disease is remarkable as it has led to the first example of a commercially available vaccine against cancer as well as against diseases caused by herpesviruses. This volume gives an overview on many aspects of MDV research and summarizes recent advances in the field. The topics include the history, biology and molecular biology of MDV, pathogenesis, vaccinal immunity, immune response, genetic resistance and development of recombinant polyvalent vaccines. It is hoped that this volume will make an important contribution towards the control of infectious diseases.
The History and Biology of Marek's Disease Virus.- Pathogenesis of Marek's Disease Virus Infection.- Protective Efficacy of Marek's Disease Vaccines.- Immune Responses to Marek's Disease Virus Infection.- Genetic Resistance to Marek's Disease.- The Genomic Structure of Marek's Disease Virus.- Protein-Coding Content of the Sequence of Marek's Disease virus Serotype 1.- A complete Genomic DNA Sequence of Marek's Disease Virus Type 2 Strain HPRS24.- Marek's Disease Virus Latency.- Meq, an MDV-Specific bZIP Transactivator with Transforming Properties.- Polyvalent Recombinant Marek's Disease Virus Vaccine Against Poultry Diseases.