Positive-Strand RNA Viruses

1. Front Matter

   Pages i-x

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2. Keynote Address

   1. The importance of antigenic variation in vaccine design

      • F. Brown

      Pages 1-8

3. Strategies for control of virus diseases

   1. Front Matter

      Pages 9-9

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   2. The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors

      • E. A. Emini, V. W. Byrnes, J. H. Condra, W. A. Schleif, V. V. Sardana

      Pages 11-17

   3. Structure-based design of symmetric inhibitors of HIV-1 protease

      • J. Erickson, D. Kempf

      Pages 19-29

   4. Age-dependent susceptibility to fatal encephalitis: alphavirus infection of neurons

      • D. E. Griffin, B. Levine, W. R. Tyor, P. C. Tucker, J. M. Hardwick

      Pages 31-39

   5. Principles and background for the construction of transgenic plants displaying multiple virus resistance

      • E. Truve, M. Kelve, A. Aaspôllu, A. Kuusksalu, P. Seppänen, M. Saarma

      Pages 41-50

   6. The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions

      • D. J. Rowlands, D. Logan, R. Abu-Ghazaleh, W. Blakemore, S. Curry, T. Jackson et al.

      Pages 51-58

   7. Immunopathologic mechanisms of dengue hemorrhagic fever and dengue shock syndrome

      • I. Kurane, A. L. Rothman, P. G. Livingston, S. Green, S. J. Gagnon, J. Janus et al.

      Pages 59-64

4. Molecular aspects of pathogenesis and virulence

   1. Front Matter

      Pages 65-65

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   2. Cardioviral poly(C) tracts and viral pathogenesis

      • A. C. Palmenberg, J. E. Osorio

      Pages 67-77

   3. Transgenic mice and the pathogenesis of poliomyelitis

      • V. R. Racaniello, R. Ren

      Pages 79-86

   4. Adaptation of positive-strand RNA viruses to plants

      • R. Goldbach, J. Wellink, J. Verver, A. van Kammen, D. Kasteel, J. van Lent

      Pages 87-97

   5. A molecular genetic approach to the study of Venezuelan equine encephalitis virus pathogenesis

      • N. L. Davis, F. B. Grieder, J. F. Smith, G. F. Greenwald, M. L. Valenski, D. C. Sellon et al.

      Pages 99-109

   6. Use of drug-resistance mutants to identify functional regions in picornavirus capsid proteins

      • A. G. Mosser, D. A. Shepard, R. R. Rueckert

      Pages 111-119

   7. Flock house virus: a simple model for studying persistent infection in cultured Drosophila cells

      • R. Dasgupta, B. Selling, R. Rueckert

      Pages 121-132

5. Genome replication and transcription

   1. Front Matter

      Pages 133-133

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   2. Protein-protein interactions and glycerophospholipids in bromovirus and nodavirus RNA replication

      • P. Ahlquist, S.-X. Wu, P. Kaesberg, C. C. Kao, R. Quadt, W. Dejong et al.

      Pages 135-145

   3. Characteristics of the poliovirus replication complex

      • K. Bienz, D. Egger, Th. Pfister

      Pages 147-157

   4. Secretory pathway function, but not cytoskeletal integrity, is required in poliovirus infection

      • J. Doedens, L. A. Maynell, M. W. Klymkowsky, K. Kirkegaard

      Pages 159-172

Positive-strand RNA viruses include the majority of the plant viruses, a number of insect viruses, and animal viruses, such as coronaviruses, togaviruses, flaviviruses, poliovirus, hepatitis C, and rhinoviruses. Works from more than 50 leading laboratories represent latest research on strategies for the control of virus diseases: molecular aspects of pathogenesis and virulence; genome replication and transcription; RNA recombination; RNA-protein interactions and host-virus interactions; protein expression and virion maturation; RNA replication; virus receptors; and virus structure and assembly. Highlights include analysis of the picornavirus IRES element, evidence for long term persistence of viral RNA in host cells, acquisition of new genes from the host and other viruses via copy-choice recombination, identification of molecular targets and use of structural and molecular biological studies for development of novel antiviral agents.

• RNA
• antigen
• cell
• hepatitis
• infection
• pathogenesis
• retroviruses
• shock
• vaccine
• virus

• Department of Biology, Georgia State University, Atlanta, USA

  Margo A. Brinton

• Arthropod-borne and Infectious Disease Laboratory (AIDL), Colorado State University, Fort Collins, USA

  Charles H. Calisher

• Institute for Molecular Virology, University of Wisconsin, Madison, USA

  Roland Rueckert

Policies and ethics