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Biomedical Sciences - Pharmacology & Toxicology | The AAPS Journal (Societies)

The AAPS Journal

The AAPS Journal

An Official Journal of the American Association of Pharmaceutical Scientists

Editor-in-Chief: Ho-Leung Fung

ISSN: 1550-7416 (electronic version)

Journal no. 12248

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New York | Heidelberg, 10 November 2012

Curcumin: the Fascinating Nutraceutical Found in your Pantry of Spices

Congratulations to the 2015 AAPS Journal Outstanding Manuscript Award winners Subash C. Gupta, Sridevi Patchva, and Bharat B. Aggarwal for their work on Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials.

Curcumin, a polyphenol found in turmeric, has been shown to combat a myriad of human diseases 

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Extensive clinical trials over the past quarter century have addressed the pharmacokinetics, safety, and efficacy of curcumin (diferuloylmethane), a component of the golden spice turmeric (Curcuma longa), against numerous diseases in humans. This study by Subash Gupta (et al.) discusses how curcumin can modulate perturbations of multiple cell signaling pathways, the cause of many complex multigenic human diseases. Curcumin has also shown protection against hepatic conditions, chronic arsenic exposure, and alcohol intoxication. In clinical trials, the nutraceutical has been used either alone or in combination with other agents. Various formulations of curcumin, including nanoparticles, liposomal encapsulation, emulsions, capsules, tablets, and powder, have been examined. In this review, the researchers discuss in detail the various human diseases in which the effect of curcumin has been investigated.
From the findings of these clinical trials, curcumin could be a highly beneficial addition to therapeutics and healthcare due to its tolerability, among its other effective characteristics.
The study concludes: “We hope that the results from ongoing clinical trials will provide a deeper understanding of curcumin’s therapeutic potential and will help to place this fascinating molecule at the fore front of novel therapeutics.”

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    The AAPS Journal, an official journal of the American Association of Pharmaceutical Scientists (AAPS), publishes novel and significant findings in the various areas of pharmaceutical sciences impacting human and veterinary therapeutics, including:

    ·         Drug Design and Discovery

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    ·         Regulatory Notes

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    ·         Protocols in the Pharmaceutical Sciences

    In addition, The AAPS Journal publishes themes, organized by guest editors, which are focused on particular areas of current interest to our field.  

     

    The AAPS Journal publishes six issues a year.

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