Sphingolipids: Basic Science and Drug Development

1. Front Matter

   Pages i-viii

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2. Basic Mechanisms

   1. Front Matter

      Pages 1-1

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   2. The Genetics of Sphingolipid Hydrolases and Sphingolipid Storage Diseases

      • Edward H. Schuchman, Calogera M. Simonaro

      Pages 3-32

   3. Sphingolipids and Membrane Domains: Recent Advances

      • Salvatore Chiantia, Erwin London

      Pages 33-55

   4. Sphingolipid Metabolism and Neutral Sphingomyelinases

      • Michael V. Airola, Yusuf A. Hannun

      Pages 57-76

   5. Acid Sphingomyelinase

      • Brian Henry, Regan Ziobro, Katrin Anne Becker, Richard Kolesnick, Erich Gulbins

      Pages 77-88

   6. Ceramide Synthases: Reexamining Longevity

      • Joo-Won Park, Yael Pewzner-Jung

      Pages 89-107

   7. Membrane Channels Formed by Ceramide

      • Marco Colombini

      Pages 109-126

   8. Genetic Disorders of Simple Sphingolipid Metabolism

      • Virginie Albinet, Marie-Lise Bats, Carmen Bedia, Frédérique Sabourdy, Virginie Garcia, Bruno Ségui et al.

      Pages 127-152

   9. The Role of Ceramide-1-Phosphate in Biological Functions

      • L. Alexis Hoeferlin, Dayanjan S. Wijesinghe, Charles E. Chalfant

      Pages 153-166

3. Drug Development

   1. Front Matter

      Pages 167-167

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   2. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs)

      • Johannes Kornhuber, Philipp Tripal, Erich Gulbins, Markus Muehlbacher

      Pages 169-186

   3. Novel Drugs Targeting Sphingolipid Metabolism

      • Krishna P. Bhabak, Christoph Arenz

      Pages 187-196

   4. The Therapeutic Potential of Nanoscale Sphingolipid Technologies

      • Jody L. Hankins, Ushma A. Doshi, Jeremy K. Haakenson, Megan M. Young, Brian M. Barth, Mark Kester

      Pages 197-210

   5. Novel Chemotherapeutic Drugs in Sphingolipid Cancer Research

      • Daniel Canals, Yusuf A. Hannun

      Pages 211-238

   6. Pharmacology of the Sphingosine-1-Phosphate Signalling System

      • Dagmar Meyer zu Heringdorf, Katja Ihlefeld, Josef Pfeilschifter

      Pages 239-253

4. Back Matter

   Pages 255-259

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Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids’ basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.

• Cell Signaling
• Cell Signaling
• Ceramides
• Ceramides
• Sphingosine-1-phosphate
• Sphingosine-1-phosphate
• Synthases
• Synthases
• acid sphingomyelinase
• acid sphingomyelinase

• , Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany

  Erich Gulbins

• Division of Pulmonary, Allergy, Critical, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA

  Irina Petrache

Erich Gulbins studied medicine at Heidelberg University, Germany, Guy’s Hospital in London, UK and the Medical School in Louisville, Kentucky, USA. He received his MD from Heidelberg University in 1992. From 1992 to 1994 he was a clinical trainee and postdoctoral fellow at the University of San Diego’s Department of Rheumatology and at the La Jolla Institute for Allergy and Immunology, La Jolla, California, USA. From 1994 to 2000 he held a Research Scientist and Assistant Professor position at the Institute of Physiology, University of Tübingen, Germany, where, in 1996, he became Professor for Physiology (Habilitation) at the Faculty of Medicine. Between 2000 and 2002 he served as an Associate Professor at the Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA. Since 2001 he has been Full Professor and Acting Chair at the University of Duisburg-Essen’s Department of Molecular Biology in Essen, Germany.

Irina Petrache studied Medicine at the Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, she received her MD in 1992. From 1992 to 1996 she was a clinical trainee and postdoctoral research fellow at the Saint Luke´s Medical Center (now Saint Vincent) Case Western Reverse University, Cleveland, OH, USA . From 1996 to 2000 she served as research scientist and clinical fellow in pulmonary and critical care at the John Hopkin´s University School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, MD, USA. From 2000 to 2003 she was instructor of Medicine and from 2000 to 2006 Co-Director of the Sarcoidosis Clinic, John Hopkin´s University School of Medicine, Baltimore. Since 2006 Irina Petrache has been Associate Professor of Medicine at the University of Indiana´s Department of Medicine and holds the Floyd and Reba Smith Chair in Respiratory Disease and has as well been Associate Professor of Biochemistry and Molecular Biology at the Department of Biochemistryand Molecular Biology.

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