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Pain Control

  • Book
  • © 2015

Overview

Editors:
  1. Hans-Georg Schaible

    1. Institute of Physiology/Neurophysiology, Jena University Hospital, Jena, Germany

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  • Highlights key mechanisms of pain generation and pain chronification
  • Addresses emerging novel concepts and targets for pain therapy
  • Addresses novel peripheral, spinal and cerebral targets for pain therapy

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 227)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. Emerging Concepts of Pain Therapy Based on Neuronal Mechanisms

    • Hans-Georg Schaible
    Pages 1-14

  3. The Pharmacology of Nociceptor Priming

    • Ram Kandasamy, Theodore J. Price
    Pages 15-37

  4. Sodium Channels and Pain

    • Abdella M. Habib, John N. Wood, James J. Cox
    Pages 39-56

  5. Role of Nerve Growth Factor in Pain

    • Kazue Mizumura, Shiori Murase
    Pages 57-77

  6. Central Sensitization in Humans: Assessment and Pharmacology

    • Lars Arendt-Nielsen
    Pages 79-102

  7. Nitric Oxide-Mediated Pain Processing in the Spinal Cord

    • Achim Schmidtko
    Pages 103-117

  8. The Role of the Endocannabinoid System in Pain

    • Stephen G. Woodhams, Devi Rani Sagar, James J. Burston, Victoria Chapman
    Pages 119-143

  9. The Role of Glia in the Spinal Cord in Neuropathic and Inflammatory Pain

    • Elizabeth Amy Old, Anna K. Clark, Marzia Malcangio
    Pages 145-170

  10. Plasticity of Inhibition in the Spinal Cord

    • Andrew J. Todd
    Pages 171-190

  11. Modulation of Peripheral Inflammation by the Spinal Cord

    • Linda S. Sorkin
    Pages 191-206

  12. The Relationship Between Opioids and Immune Signalling in the Spinal Cord

    • Jacob Thomas, Sanam Mustafa, Jacinta Johnson, Lauren Nicotra, Mark Hutchinson
    Pages 207-238

  13. The Role of Proteases in Pain

    • Jason J. McDougall, Milind M. Muley
    Pages 239-260

  14. Amygdala Pain Mechanisms

    • Volker Neugebauer
    Pages 261-284

  15. Itch and Pain Differences and Commonalities

    • Martin Schmelz
    Pages 285-301

  16. Back Matter

    Pages 303-309
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Keywords

About this book

This volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in different tissues and in inflammatory and neuropathic pain states, and the contribution of proteinase activated receptors (PAR) to the development of pain in several chronic pain conditions. Chapters on nociceptive mechanisms in the spinal cord address the particular role of NO and of glial cell activation in the generation and maintenance of inflammatory and neuropathic pain and it discusses the potential role of local inhibitory interneurons, of the endogenous endocannabinoid system and the importance of non-neuronal immune mechanisms in opioid signaling in the control of pain. Furthermore, it is presented how spinal mechanisms contribute to the expression of peripheral inflammation.

Editors and Affiliations

  • Institute of Physiology/Neurophysiology, Jena University Hospital, Jena, Germany

    Hans-Georg Schaible

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